研究者发现TM4SF1-AS1的H3K4me3在GC患者中特异性上调,TM4SF1-AS1在原代和培养的GC细胞中的表达显著上调。TM4SF1AS1在体内外促进胃癌细胞的生长,其致癌作用至少部分是通过与富嘌呤元件结合蛋白α(PUR-α)和Y盒结合蛋白1(YB-1)的相互作用来实现的。TM4SF1-AS1还激活GC细胞中的干扰素信号,这依赖于Pur-α和RIG-I...
研究者发现TM4SF1-AS1的H3K4me3在GC患者中特异性上调,TM4SF1-AS1在原代和培养的GC细胞中的表达显著上调。TM4SF1AS1在体内外促进胃癌细胞的生长,其致癌作用至少部分是通过与富嘌呤元件结合蛋白α(PUR-α)和Y盒结合蛋白1(YB-1)的相互作用来实现的。TM4SF1-AS1还激活GC细胞中的干扰素信号,这依赖于Pur-α和RIG-I...
TM4SF1-AS1 contributes to GC cell growth in vitro and in vivo, and its oncogenic function is mediated, at least in part, through interactions with purine-rich element-binding protein 伪 (Pur-伪) and Y-box binding protein 1 (YB-1). TM4SF1-AS1 also activates interferon signaling in GC ...
TM4SF1-AS1在结直肠癌肿瘤组织中高表达,并且其高表达预示更短的OS和DFS;单因素和多因素Cox回归模型表明TM4SF1-AS1的表达是结直肠癌的独立预后因素.RT-PCR实验显示TM4SF1-AS1在人结直肠癌细胞株(HCT116,SW620,SW480,HT29)中的相对表达量高于人正常结肠粘膜细胞株(FHC);TM4SF1-AS1 siRNA下调结直肠癌细胞株...
lncRNA TM4SF1-AS1miR-744-3pBackground:Cholangiocarcinoma (CCA) is of great malignancy and high mortality. Identification of effective biomarkers could improve the monitoring of CCA development and attenuate patients' outcomes. Objective:The potential of lncRNA TM4SF1-AS1 (TM4SF1-AS1) serving ...
After silencing the expression of LncTM4SF1-AS1, the expression levels of TM4SF1 in the shTM4SF1-AS1 group were downregulated compared to those in the shControl group, and the p-PI3K and p-AKT proteins in the PI3K-AKT signalling pathway in the shTM4SF1-AS1 group were downregulated ...
In vivo assays revealed TM4SF19-AS1 depletion restrained HNSCC tumor growth. Additionally, mechanism experiments were implemented to uncover the underlying regulatory mechanism of TM4SF19-AS1 in HNSCC cells. It turned out that TM4SF19-AS1 modulated laminin subunit gamma 1 (LAMC1) expression via ...
To summarize, TM4SF19-AS1 played an oncogenic role in HNSCC cells, signifying TM4SF19-AS1 may have the potential to be used as a novel molecular target for HNSCC diagnosis.Taylor And FrancisCancer Biology And Therapy
TM4SF19-AS1相对表达量是显著高于对照组的,其差异经过统计分析后,具有统计学意义(P<0.01);缓解组中结果表明,其骨髓血单个核细胞中LncRNA TM4SF19-AS1相对表达量高于复发难治组和初治组,经过统计分析后,其结果表明它们之间的差异有统计学意义(P<0.05);初治组骨髓血的单个核细胞中,LncRNA TM4SF19-AS1相对...
LncRNA TM4SF19-AS1 Promotes the Proliferation, Migration and Invasion of Laryngeal Squamous Cell Carcinoma by Targeting miR-153-3p/ITGAV Axisdoi:10.21203/rs.3.rs-720370/v1Yudong LiuXiaojuan FengYuexin TianBaoshan Wang