TLR7 / 8 Ligands TLR7 / 8 Ligands - InvivoGenInvivogen, T L R Ligands
As TLR7 activates both the NF-κB and IRF signaling pathways, InvivoGen also offersHEK-Dual™ hTLR7 cells; a cell line expressing a dual reporter system comprising an NF-κB-inducible SEAP and an IRF-inducible Lucia luciferase(learn morehere). ...
1 ml Normocin™ (50 mg/ml) 1 pouch of HEK-Blue™ Detection (cell culture medium for real-time detection of SEAP) Shipped on dry ice (Europe, USA, Canada and some areas in Asia) Back to the top Details Toll-Like Receptor 7 In humans, four Toll-Like Receptor (TLR) family ...
InvivoGen expands its collection of human monocyticreporter cell linesdesigned to monitor the intertwined NF-κB and IRF responses of the Toll-Like Receptor 7 (TLR7). Trafficking and signaling in THP1-Dual™ TLR7/8 cells THP1-Dual™ hTLR7 cellsandTHP1-Dual™ hTLR7 KO-TLR8 cellswere ...
BMS-986256 is currently under phase II clinical investigation in patients with systemic lupus erythematosus (SLE) [3, 4]. BMS-986256 efficiently inhibits human (h)TLR7, mouse (m)TLR7, and hTLR8, but not mTLR8, as assessed using InvivoGen's HEK-Blue™ reporter cell lines overexpressing...
Vaccigrade Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a sterile TLR7 agonist with a potent antiviral activity. InvivoGen Vaccigrade Imiquimod (≥95% HPLC) is functionally tested on TLR7 cellular assay, guaranteed endotoxin-free,
M5049 efficiently inhibits human (h)TLR7, mouse (m)TLR7, and hTLR8, but not mTLR8, as assessed using InvivoGen's HEK-Blue™ reporter cell lines overexpressing hTLR7, mTLR7, hTLR8, and mTLR8 (see figures). M5049 exerts inhibitory actions on both NF-κB and IRF pathways downstream...
Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a TLR7 agonist with a potent antiviral activity. InvivoGen Imiquimod for research (≥95% HPLC) is ready to use, functionally tested on TLR7 cellular assay, and guaranteed endotoxin-free.
R848 (Resiquimod), an imidazoquinoline, is a dual TLR8 and TLR7 synthetic agonist with potent antiviral activity. InvivoGen R848 (≥95% HPLC) is water soluble, functionally tested on TLR7 and TLR8 cellular assays, and guaranteed endotoxin-free. Resiquimo
Gardiquimod™ is an imidazoquinoline compound developed and manufactured by InvivoGen. Gardiquimod™ is a human or mouse TLR7-specific agonist. Gardiquimod™ is 10 times more potent than Imiquimod. Each lot is highly pure and functionally tested.