It was shown that increased expression of IL1B and TLR2 genes is associated with the development of frailty in nonagenarians and can be a factor of pathological aging. Increased expression of IL10 gene can be considered as a factor of successful aging in nonagenarians....
结论1生物信息学分析及小鼠实验验证结果均提示,TLR2和IL1B是玫瑰痤疮皮损组织中关键基因.2沙利度胺可能通过抑制CathelicidinLL37介导的TLR4/MyD88/NF-κB信号通路... 何阳 - 华北理工大学 被引量: 0发表: 2022年 基于生物信息学方法对结肠黏液腺癌预后相关基因的筛选及分析 IL...
1 Myd88 is required for MHV-induced inflammatory responses. (a and b) Real-time PCR analysis of the expression of Il1b (a) and Il6 (b) in WT, Myd88–/–, and Trif–/– bone marrow-derived macrophages (BMDMs) after infection with MHV at an MOI of 0.1 for the indicated time, ...
由于任何抗oxpl抗体都具有减少炎症过程的能力,包括减少il-1b的产生的能力,以及在tlr2介导的川崎病小鼠模型中提供保护的能力,因此注射经过修饰以增强其生物有效性的人源化或人等价的抗-oxpl抗体可能会赋予针对tlr2相关疾病(包括川崎病)的保护。由于此类抗oxpl抗体存在于人b细胞库中,因此靶向重组治疗可为此类疾病带来...
由于任何抗OxPL抗体都具有减少炎症过程的能力,包括减少IL-1B的产生的 能力,以及在TLR2介导的川崎病小鼠模型中提供保护的能力,因此注射经过修饰以增强其 生物有效性的人源化或人等价的抗-OxPL抗体可能会赋予针对TLR2相关疾病(包括川崎病) 的保护。由于此类抗OxPL抗体存在于人B细胞库中,因此靶向重组治疗可为此类...
(delta a,delta b,delta c),炎性细胞因子(il1b,il10,il6,tnfa及ifnphi),趋化因子(ccl-c5a,cxcl-8a)和TLR信号通路上的关键因子(tlr2,tlr4,myd88,mmp9... 董雪红 - 《上海海洋大学》 被引量: 1发表: 2015年 A novel inhibitory role of microRNA‐224 in particulate matter 2.5‐induced asthmatic...
Surprisingly, transcript levels of various inflammatory genes including Tnfa, Il6, Il1b, and il18 in the lungs were comparable between WT and DKO mice (Figure 7H). This finding is reminiscent of an early study showing that lethal toxin derived from Clostridium sordellii increases lung ...
HEK-Blue™ hTLR2 KO-TLR1/6 cells have been stimulated by various pathogen recognition receptor (PRR) agonists. As expected, these cells produce SEAP in response to NF-κB activators, such as IL-1β or TNF-α. The expression of human TLR2 (hTLR2) and CD14 in this cell line has be...
A second pathway of MDP response to PnCW was also dependent on NOD2 sensing appears to be involved in IL-1b processing and is (Figs 1B, D and E). The reduction in IL-10 production from mediated by NLR family members Cryopyrin (NLRP3) and PnCW-stimulated NOD-deficient macrophages ...
higher amounts of IL-6 and TNF-a secretion than conditioned medium from non-metastatic cells (Fig. 1a). IL-1b secretion was undetectable and the conditioned medium did not contain IL-6 or TNF-a (data not shown). LCM also induced expression of Il1b, Il6 ...