TLR2-activated human langerhans 261 cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. European journal of immunology 39: 1221-30.Aliahmadi, E. et al. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol 39, ...
THE ATTENUATION OF IL‐1BETA RESPONSE IN MAC‐LD IS DUE TO BOTH DECREASES OF NLRP3 INFLAMMASOME AND TLR2 ACTIVATIONinflammasomeactivation pathwaytranscription pathwaymacrophageMycobacterium avium complexdoi:10.1111/resp.13207_30NoneJohn Wiley & Sons, LtdRespirology...
Dimerization of TLR2 with TLR1 was inhibited by the n-3 fatty acid docosahexaenoic acid. Activation of TLR2 by palmitic acid leads to expression of pro-IL-1 beta that is cleaved by caspase-1, which is constitutively present in monocytes, to release mature IL-1 beta. Our results reveal ...
Glucocorticoids synergize with IL-1β to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells ACB, Akira S, Li JD: Glucocorticoids synergize with IL-1 beta to induce TLR2 expression via MAP kinase phosphatase-1dependent dual inhibi...
(NF-κB), with the subsequent increase in the expression of pro-inflammatory cytokines such as interleukin 1 beta ( IL-1β) and tumor necrosis factor alpha (TNFα) [3,5,7]. TLR4 signaling can also elicit the synthesis of interferon beta (IFNβ) [8]. Besides, the activation of TLR2 ...
Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB 2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol. 2002;22(20):7158–67. ...
TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of ...
TLR2- and Dectin 1–Associated Innate Immune Response Modulates T-Cell Response to Pancreatic β-Cell Antigen and Prevents Type 1 Diabetes Karumuthil-Melethil, S., et al., TLR2- and Dectin 1-associated innate immune response modulates T-cell response to pancreatic beta-cell antigen and preve...
细胞免疫荧光分别从m RNA和蛋白水平检测不同处理组小鼠巨噬细胞IL-6,IL-1β及TNF-α的表达状况,观察TLR2能否介导β2GPI/抗β2GPI复合物促进巨噬细胞表达炎性因子.(4)qRT-PCR检测TLR2阻断剂和TLR4阻断剂预处理后β2GPI/抗β2GPI诱导的小鼠巨噬细胞MCP-1和TF的m RNA表达,ELISA检测MCP-1分泌水平,活性试剂...
TGF-beta down-regulates IL-1alpha-induced TLR2 expression in murine hepatocytes. J Leukoc Biol 2004;75:1056-61. :Matsumura T, Hayashi H, Takii T, Thorn CF, Whitehead AS, et al. (2004) TGF-beta down-regulates IL-1alpha-induced TLR2 expression in murine hepatocytes. J Leukoc Biol 75:...