et al. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol 39, 1221-1230 (2009).Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M. TLR2-activated human...
Activation of TLR2 by palmitic acid leads to expression of pro-IL-1 beta that is cleaved by caspase-1, which is constitutively present in monocytes, to release mature IL-1 beta. Our results reveal mechanistic insight about how palmitic acid activates TLR2, upregulates NALP3 expression, and ...
Glucocorticoids synergize with IL-1β to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells ACB, Akira S, Li JD: Glucocorticoids synergize with IL-1 beta to induce TLR2 expression via MAP kinase phosphatase-1dependent dual inhibi...
THE ATTENUATION OF IL‐1BETA RESPONSE IN MAC‐LD IS DUE TO BOTH DECREASES OF NLRP3 INFLAMMASOME AND TLR2 ACTIVATIONinflammasomeactivation pathwaytranscription pathwaymacrophageMycobacterium avium complexdoi:10.1111/resp.13207_30NoneJohn Wiley & Sons, LtdRespirology...
(NF-κB), with the subsequent increase in the expression of pro-inflammatory cytokines such as interleukin 1 beta ( IL-1β) and tumor necrosis factor alpha (TNFα) [3,5,7]. TLR4 signaling can also elicit the synthesis of interferon beta (IFNβ) [8]. Besides, the activation of TLR2 ...
Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB 2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol. 2002;22(20):7158–67. ...
TLR2-and Dectin 1-Associated Innate Immune Response Modulates T-Cell Response to Pancreatic beta-Cell Antigen and Prevents Type 1 Diabetes 来自 国家科技图书文献中心 喜欢 0 阅读量: 26 作者:Gudi,Radhika,Vasu,Chenthamarakshan,Perez,Nicolas,Sofi,M.,Hanief,Karumuthil-Melethil ...
细胞免疫荧光分别从m RNA和蛋白水平检测不同处理组小鼠巨噬细胞IL-6,IL-1β及TNF-α的表达状况,观察TLR2能否介导β2GPI/抗β2GPI复合物促进巨噬细胞表达炎性因子.(4)qRT-PCR检测TLR2阻断剂和TLR4阻断剂预处理后β2GPI/抗β2GPI诱导的小鼠巨噬细胞MCP-1和TF的m RNA表达,ELISA检测MCP-1分泌水平,活性试剂...
granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in ...
(TLR2). To date, at least ten members of the Toll family have been identified in human. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of th...