Glioblastoma (GBM) is the most common and deadly malignant brain cancer, with a median survival of <2 years. GBM displays a cellular complexity that includes brain tumour-initiating cells (BTICs), which are considered as potential key targets for GBM
[7, 8] Many studies have fully verified that miRNAs can regulate cell proliferation of osteosarcoma [9, 10]. Thus, anti-sense miRNA and miRNA mimetics have capability to serve as gene therapy for osteosarcoma. However, the inherent obstacles associated with small RNAs, for exam- ple poor ...