Ex vivo characterization of ILC3 shows that TL1A synergy with IL-23 is independent of IL-1R and MyD88 signaling and not reproduced by related TNFSF (OX40L, TRAIL, or TNF伪). To evaluate the signaling pathway for TL1A-mediated synergy, soluble inhibitors revealed a critical role f...
synergy occurs when the T cell receptor is weakly stimulated or T cells are treated with IL-12. Although in Bamias et al. no synergy is observed when TL1A treatment is combined with IL-18, this result may not be surprising because both IL-18 and TL1A signal through NF-κB. Whereas ...
No difference in Th1, Th17, Treg, Foxp3/RORgt+ CD4+ T, or ILC2 production of IL-13 was seen, suggesting a critical role for DR3 signaling in ILC3 in vivo. Our data in ILC3 show that TL1A synergy with IL-23 is independent of IL-1R and MyD88 signaling and not compl...