Introduction: The TJ, which helps regulate the intestinal permeability (IP) barrier, is composed of both cytosolic proteins such as ZO-1 and transmembrane proteins such as claudin-1. Increased IP is present in intestinal inflammation. Stat6 regulates cytokine induced gene expression through the IL-...
Disrupted tight (Yap/ZO-1) and adherens (Yap/伪-Catenin) junction proteins underlie time-dependent apoptotic cell death of epidermal keratinocytes. Thus, ... Ritesh Kumar Srivastava,Suhail Muzaffar,Jasim Khan,... - Scientific Reports 被引量: 0发表: 2025年 DISTRIBUTING FILES ACROSS MULTIPLE, PE...
Lately some TJ proteins like the MAGUK ZO-1 and ZO-2, MAGI 1c, as well as the unrelated proteins symplekin and ubinuclein, have been found to concentrate at the nucleus. In this chapter we describe such proteins and how their arrival to the nucleus is connected to the degree of cell-...
The epithelial TJ is a complex of numerous transmembrane and peripheral membrane proteins. The latter, including ZO-1, may be critical to cytoskeletally-mediated TJ regulation, but this hypothesis has not been tested experimentally. We recently found that ZO-1, which binds directly to actin and ...
Our results show that CTR activates AKAP2-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3. Moreover, PKA-mediated phosphorylation of tight unction proteins required CTR-ZO-1 interaction, suggesting that the interaction may bring CTR-...
Tight junction (TJ) proteins (Tjps), Tjp1 and Tjp2, are tight junction-associated scaffold proteins that bind to the transmembrane proteins of tight junctions and the underlying cytoskeleton. In this study, we first analyzed the tumorigenic characteristics of B16-F10 melanoma cells, ...
ZO-1,Cx43 were determined by Western blotting.Results:BPA perturbs the integrity of the TJ-permeablity in Sertoli cells in vitro,which was associated with the decline of selected proteins at the tight junction,and gap junction at the blood-testis barrier.The expression of Cx43 increased while...
Little changes in protein and RNA levels were seen, indicating redistribution of proteins. In cultured keratinocytes, a reduction of transepithelial resistance was observed. Staphylococcus epidermidis shows only minor effects. All strains induced enhanced expression of occludin and ZO-1 at the beginning ...