T lizanidine is an alpha2-adrenoceptor agonist that is structurally related to clonidine. It acts on the central nervous system, mainly in the spine and brain, to inhibit excitatory intemeurons and relax skeletal muscle. Tizanidine is used for the symptomatic relief of spasticity associated with ...
Does tizanidine interact with other medicines (drug interactions)? Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. In particular, make sure that you discuss if you are using an...
Tizanidine is a skeletal muscle relaxant. It works on alpha2 receptors in the central nervous system (brain and spinal cord) and blocks nerve impulses from reaching muscles which produces muscle relaxation. Tizanidine is used for the treatment and management of skeletal muscle spasticity. Spasticity ...
Because of potential drug interactions, tizanidine is contraindicated in patients taking potent CYP1A2 inhibitors, such as fluvoxamine or ciprofloxacin. Adverse reactions such as hypotension, bradycardia, or excessive drowsiness can occur when tizanidine is taken with other CYP1A2 inhibitors, such as zil...
Because of potential drug interactions, concomitant use of Zanaflex with other CYP1A2 inhibitors, such as zileuton, fluoroquinolones other than strong CYP1A2 inhibitors (which are contraindicated), antiarrhythmics (amiodarone, mexiletine, propafenone, and verapamil), cimetidine, famotidine, oral contracept...
Drug Interactions for Zanaflex Fluvoxamine Concomitant use of fluvoxamine and Zanaflex is contraindicated. Changes in pharmacokinetics of tizanidine when administered with fluvoxamine resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment [see CONTRAINDICATIONS...
Drug Interactions Tizanidine may interact with other medications‚ supplements‚ or herbal products‚ which can affect its effectiveness‚ increase the risk of side effects‚ or lead to potential drug interactions. It is important to inform your healthcare provider about all the medications you...
Drug Class:Alpha2 adrenergic agonists What is tizanidine, and what is it used for? Tizanidine is a medication used in the management of muscle spasticity, a condition with high muscle tone and stiffness that leads topainand impaired mobility. ...
5.5 Interaction with CYP1A2 Inhibitors Because of potential drug interactions, Tizanidine tablets is contraindicated in patients taking potent CYP1A2 inhibitors, such as fluvoxamine or ciprofloxacin. Adverse reactions such as hypotension, bradycardia, or excessive drowsiness can occur when tizanidine tablets...
Tizanidine is an α2-adrenergic agonist that can produce hypotension [see Adverse Reactions (6.1) and Drug Interactions (7.5)]. Syncope has been reported in patients treated with tizanidine in the postmarketing setting. The risk of hypotension may be minimized by dose titration; monitoring for sig...