Early-onset lone AF cohort: A total of 399 unrelated early-onset AF subjects were recruited using the Danish National Patient Registries and ICD-10 code I48.9. Only patients with onset of disease before the age of 40 were included. Patients with cardiovascular diseases (mitral valve/aortic valve...
Additionally, an ICD was implanted, genetic investigations initiated, and the patient was scheduled for heart transplantation (HTX). Genetic testing by means of a gene panel covering 40 genes associated with dilated CMP (dCMP) revealed the heterozygous mutation c.1489G > T (p. E497X) in exon...