samples from 59 tissue types, originating from 185 mammalian species across 19 taxonomic orders (Supplementary Data1.1–1.4and Supplementary Notes1and2) with ages ranging from prenatal to 139 years old (bowhead whale,Balaena mysticetus)9. These data are a subset from our Mammalian Methylation Consor...
2c per-class testing accuracy as a function of percentage of annotations used. Rights and permissions Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript ...
Let us introduce a material symmetry group Gk with respect to a local reference configuration, which characterizes the anisotropy class of the material. The elements of Gk are denoted by the unimodular tensors iQ∣i = 1, … , n. The concept of material symmetry requires the constitutive ...
B2M is the invariant chain of MHC class I that becomes elevated with inflammation and based on current reports is over-pronounced in old muscle and brain, as compared with young8,14,20. B2M levels were assayed by immunofluorescence in tissue cryosections (Fig. 4a,b) and by western blotting...
RNA and protein expression fold changes between inner ear tissues. For mRNA differential expression and fold-change estimation we used the edgeR package, with a detection threshold ofq − value ≤ 0.05. For protein we used the samr package (two class unpaired test) with thresholdq ...
Thus, they would mostly fit a class of core promoters dubbed "dispersed" that are evolutionary younger and more common in vertebrates and whose exact mechanisms of regulation by transcription factors are less understood than those of the class termed "focused" [55]. The most prominent individual ...
Single-cell RNA-sequencing has emerged as a powerful technique for characterizing cellular heterogeneity, but it is currently impractical on large sample cohorts and cannot be applied to fixed specimens collected as part of routine clinical care. We prev
Single-cell RNA sequencing methods can profile the transcriptomes of single cells but cannot preserve spatial information. Conversely, spatial transcriptomics assays can profile spatial regions in tissue sections, but do not have single-cell resolution.
Author notes Authors and Affiliations Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej 15, Gliwice, 44-101, Poland Aleksandra Pfeifer, Bartosz Wojtas, Malgorzata Oczko-Wojciechowska...
Transcription termination is a crucial step in the production of conforming mRNAs and functional proteins. Under cellular stress conditions, the transcription machinery fails to identify the termination site and continues transcribing beyond gene boundar