Semi-supervised Nonnegative Matrix Factorization for gene expression deconvolution: a case study. Infect Genet Evol 12, 913–921 (2012). 14. Schwartz, R. & Shackney, S. E. Applying unmixing to gene expression data for tumor phylogeny inference. BMC Bioinformatics 11, 42, doi: 10.1186/1471-...
The x and y coordinates of the cells are standardized via the StandardScaler() function, and the data was fed into a SVM with a radial basis function (RBF) kernel with balanced class weights and one vs. one decision function. The RBF SVM model is then applied to a meshgrid with a fine...
The case of NAP1L2 (nucleosome assembly protein 1-like 2) is particularly interesting. Although, according to Pubmed, 'the function of this family member is unknown, mouse studies suggest that it represents a class of tissue-specific factors interacting with chromatin to regulate neuronal cell ...
Here, we demonstrate how to model a class of FMCs that can reconstruct human cell population dynamics that start or recur at different times during life, using standard Illumina EPIC methylation arrays applied to bulk tissue samples. Large numbers of fCpG sites reversibly flip–flop their methylati...
[139,140]. A randomized controlled clinical trial over 12 months has shown that the use of calcium sulphate is useful in minimizing post-surgical recession when compared with the use of collagen membrane [139]. The clinical outcome of class II mandibular molar furcation defects has also been ...
MADS-box genes are master regulators of floral structures; PISTILLATA (PI) is a class B gene in the ABC model, regulating the formation of petals and stamens, while AGAMOUS (AG) is a C-class gene that regulates the development of stamens and pistils in Arabidopsis.31 Expression of some ...
Our original observations also include that HDAC8, a class I HDAC, is predominantly detected in the cytoplasm of smooth muscle cells rather than in the nuclear compartment, both in vivo and in vitro. The prominent cytosolic expression of HDAC8 observed in this current study contrasts with a pre...
Thus, they would mostly fit a class of core promoters dubbed "dispersed" that are evolutionary younger and more common in vertebrates and whose exact mechanisms of regulation by transcription factors are less understood than those of the class termed "focused" [55]. The most prominent individual ...
In this case, if the differentia- tion of cryptopatches into ILFs could be inhibited, this could lead to a novel class of treatments for IBD. For example, because ROR-γt is specifically expressed by intestinal Lin–cKIT+IL-7Rα+ cells (and by immature thymocytes)12 and because it is ...
Thus, CODA establishes a means to transform broadly the structural study of human diseases through exploration of exhaustively labeled 3D microarchitecture.This is a preview of subscription content, access via your institution Access optionsAccess Nature and 54 other Nature Portfolio journals Get Nature...