Due to the presence of endogenous ECM and improved cell–cell interactions, spheroids better mimic the microenvironment found in native tissue12,13. The function of numerous cell types and tissues is under investigation when formed as spheroids, including hepatocytes14, cardiomyocytes15, pancreatic ...
Muscle, contractile tissue found in animals, the function of which is to produce motion. Muscle cells fuel their action by converting chemical energy in the form of adenosine triphosphate (ATP), which is derived from the metabolism of food, into mechanic
You may have symptoms of several types of connective tissue disorders. This can make diagnosis difficult. Over time, you may develop one type of connective tissue disorder.Blood tests may be used to measure the amount of inflammation in your body or to check organ function. Blood tests may ...
the muscles, in the intestines and in their membrane folds, around theheart, and elsewhere. It is also found in thebone marrow, where it imparts a yellow colour; yellow marrow is most abundant in adults. The fat stored in adipose tissue comes from dietary fats or is produced in the ...
. We found that inks comprising a total polymer concentration below 15 w/w % are prone to spreading, which compromises shape fidelity, whereas inks with polymer concentration exceeding 25 w/w % are difficult to extrude due to clogging in the printing nozzles. Inks within the intermediate range...
Notably, Peng and colleagues found that co-culturing bone marrow mesenchymal stem cells (BMSCs) with ginseng-derived nanovesicles resulted in the internalization of numerous miRNAs from the PDNVs into the BMSCs. These specific miRNAs were found to target genes associated with the regulation of ...
Both studies found that MAP2 was a reliable staining method for all investigated occlusion and reperfusion time points. So overall, the studies point to MAP2 stains as being reliable at different occlusion and reperfusion times. It is well-known that HE stains all types of cells, including ...
Most native ECMs found in tissues or organs (e.g. sciatic nerve, heart, tendon, and blood vessel), however, have anisotropic architecture, which is important for tissue function [8]. Therefore, a well-defined architecture is believed to be necessary in order to precisely imitate native ECM ...
well-stained areas and poorly-stained areas. Supplementary Fig.1illustrates the workflow of this quantification process, and additional details can be found in the Methods section. These analyses revealed that autolytic tissues were predominantly found in four autopsy slides, exhibiting low-quality staini...
Cardiac muscle is the functional unit of the heart, as it is involved in force generation and propagation of electrical signals through the CM-rich tissue to allow rhythmic pump contraction. Human cardiac muscle is composed of various cell types, the most abundant being CMs, pericytes, endothelial...