Due to the presence of endogenous ECM and improved cell–cell interactions, spheroids better mimic the microenvironment found in native tissue12,13. The function of numerous cell types and tissues is under investigation when formed as spheroids, including hepatocytes14, cardiomyocytes15, pancreatic ...
In these bioartificial structures, the tissue compartments must be scaled to mimic nutrient transport existent within natural capillary beds found in the body. Generally, these in vivo beds are composed of 100 μm thick tissue slabs sandwiched by vasculature. Thus, the microenvironment of ex vivo ...
. We found that inks comprising a total polymer concentration below 15 w/w % are prone to spreading, which compromises shape fidelity, whereas inks with polymer concentration exceeding 25 w/w % are difficult to extrude due to clogging in the printing nozzles. Inks within the intermediate range...
Notably, Peng and colleagues found that co-culturing bone marrow mesenchymal stem cells (BMSCs) with ginseng-derived nanovesicles resulted in the internalization of numerous miRNAs from the PDNVs into the BMSCs. These specific miRNAs were found to target genes associated with the regulation of ...
4A) [121]. Similarly, micro-channeled hydrogel patch was bio-printed to treat infracted patients [122]. Further, multicellular spheroids were printed onto a needle array to make a tubular construct to develop a heart tissue [123,124]. This tissue was used to assess the therapeutic response,...
Here, we provide the first direct evidence in the intact heart that the cells in myocardial scar tissue are electri- cally coupled to the surrounding myocardium and can support the passive conduction of action potentials. Using models of cardiac injury that produced transmural scars, we demonstrate...
Bdnf was highly expressed in the brain, whereas intermediate expression was found in the heart, lung, and kidney (Figure 1a). Bdnf was also expressed in adipose tissue, although its expression was much lower than in neural tissues. In addition, Ntrk2 (the gene coding for TrkB) was ...
In both tissues, the predominant cell is the adipocyte, comprising between one- and two-thirds of the total, and the remaining tissue is composed of different types of cells constituting the stromal vascular fraction (SVF). White Adipose Tissue Although WAT is distributed throughout the body, ...
They are cells found on skin, GI tract, respiratory tract and urinary tract that are characterized by continuous regeneration. Quiescent cell types found in most of the internal organs like liver, kidney, endocrine and mesenchymal cells (fibroblasts, smooth muscle, vascular) have limited regenerative...
Further details on descriptive statistics can be found in Table 1. TET and TEG groups received an insertion of self-inflating osmotic expanders (mean 31.4 days) before bone augmentation. Mean soft tissue measurements at the end of its expansion (visit IV) were similar in both TET and TEG ...