Tissue-specific expression and functional analysis of C. elegans P-glycoprotein genes.A, BroeksCr, LinckePe, SatijnP, BorstRha, Plasterk
To investigate the tissue-specific effects of mt-tRNAs, we performed a comprehensive analysis of mitochondrial tRNA expression across five mice tissues (brain, heart, liver, skeletal muscle, and kidney) using Northern blot analysis. Striking differences in the tissue-specific expression of 22 mt-...
Additionally, genes that followed a specific expression pattern with aging were separately used for pathway enrichment analysis (for details visit https://osf.io/4fe3r/ and https://osf.io/4bvm5/). Pathways with a FDR adjusted P value lower than 0.05 were considered significantly regulated and...
two sided correlationPvalue = 1.43E−12). More in depth analysis of eQTL statistics revealed that the expression level of tissue-specific genes (Tau ≥ 0.8, TSI ≥ 0.3) was regulated by a lower
In recent years, the maturation of microarray technology has allowed the genome-wide analysis of gene expression patterns to identify tissue-specific and ubiquitously expressed ('housekeeping') genes. We have performed a functional and topological analysis of housekeeping and tissue-specific networks to ...
The simplest definition of cis-eQTLs versus trans, refers to genetic variants that affect expression in an allele specific manner, with implications on underlying mechanism. Yet, due to technical limitations of expression microarrays, the vast majority o
Tissue-Specific Expression Patterns in the Interactome Full size image To illustrate the impact of tissue-specific gene expression patterns on the interactome, consider prefrontal cortex tissue, in which only 2, 644 of the 10, 434 expressed genes are expressed with significancezE ≥ 1.0. We ...
In order to derive specific biological insights from the broad association loci implicated by MTAG, we performed a series of analyses designed to identify individual gene expression changes associated with cognition. First, we performed transcriptome wide analysis (TWAS) using MetaXcan (Barbeira et al...
GA-binding protein HSA21 Tissue-specific regulation Down syndrome 1. Introduction Down syndrome (DS), a result of trisomy human chromosome 21 (HSA21), occurs at a frequency of ∼1/700 live births [1] and results in a number of distinct pathologies with varying expressivity. DS individuals ...
The present invention relates to a synthetic regulatory element for tissue specific gene expression. Furthermore, the invention relates to a tumor cell specific expression system fo