Tissue-resident memory T cells (TRM) serve as the frontline of host defense, playing a critical role in protection against invading pathogens. This emphasizes their role in providing rapid on-site immune responses across various organs. The physiological significance of TRMis not just confined to i...
A. Percentage of CXCR3+ on antigen-experienced resident memory T cells (CD44 + CD69 + T cells) and antigen-experienced non-resident memory T cells (CD44 + CD69- T cells) in the lungs of uninfected, primary infection-cured and secondary infection-cured mice. n = 2 mi...
In the past decade, several studies shed light on tissue-resident immunity and went beyond the “strict limits” between innate and adaptive immunity. It is now well known that, apart from circulating immune cells, which are activated upon antigen encounter by the first line of defense and then...
Macrophages have long been considered as particularly plastic cells. However, recent work combining fate mapping, single-cell transcriptomics and epigenetics has undermined the macrophage plasticity dogma. Here, we discuss recent studies that have carefu
Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge[J]. Immunity, 2010, 33(1): 96-105.. Google Scholar [28] TUMPEY T M, GARCÍA-SASTRE A, TAUBENBERGER J K, et al. Pathogenicity of influenza viruses with ...
Immune cells were traditionally considered as major pro-inflammatory contributors. Recent advances in molecular immunology prove that immune cell lineages are composed of different subsets capable of a vast array of specialized functions. These immune ce
In contrast to activation-induced cytokines, expression of the anti-apoptotic cytokine IL-15, implicated in the development and maturation of memory CD8+ T cells (Jabri and Abadie, 2015), was restricted to MAIT cells in their resting states: human unstimulated MAIT cells or murine MAIT cells ...
Hartnell F.et al.(2020). Characterising HCV specific CD4+ T-cells following viral-vectored vaccination, directly acting anti-virals and spontaneous viral cure.https://doi.org/10.1002/hep.31160 Cianciotti B.et al.(2019). CD4+ memory stem T cells recognizing citrullinated epitopes are expanded in...
Immune cells were traditionally considered as major pro-inflammatory contributors. Recent advances in molecular immunology prove that immune cell lineages are composed of different subsets capable of a vast array of specialized functions. These immune ce
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), has provoked more than six million deaths worldwide and continues to pose a major threat to global health. Enormous efforts have been made by r