TF-011-MMAE (HuMax-TF-ADC) was the most potent ADC, and the dominant mechanism of action in vivo was auristatin-mediated tumor cell killing. Importantly, TF-011-MMAE showed excellent antitumor activity in patient-derived xenograft (PDX) models with variable levels of tissue factor expression, ...
Through co-targeting tissue factor (TF) and CD3, TF-TCB can recruit T cells to tumor cites, induce T cell activation, tumor cell lysis and T cell proliferation. Nivolumab further enhances TF-TCB efficacy by blocking PD-1/PD-L1 interaction. Download: Download high-res image (270KB) Download...
2016). This work well extends the role of SWI/SNF complex in oligodendrocyte differentiation and maturation described in a previous study, where Brg1 is recruited by the determination factor Olig2 to cis-regulatory elements of essential factors responsible for oligodendrocyte differentiation, such as S...
Tissue factor (TF), the transmembrane receptor for factor VIIa (FVIIa), has key regulatory functions in coagulation as well as in tumour progression and metastasis. Small-cell lung cancer (SCLC) metastasises more aggressively than non-small-cell lung cancer (NSCLC). Previously, we described the...
Further, gene set enrichment analysis (GSEA) indicated that macrophages that had received mitochondria from adipocytes were enriched in genes associated with the hypoxia-inducible factor (HIF)-1α/tissue factor (TF) pathway (Figure 3K) and de-enriched for genes associated with electron transport (...
The FOXP3+CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have distinct transcriptomes, T cell receptor repertoires and growth and survival factor d
Patients with chronic kidney disease (CKD) commonly exhibit hypercoagulability. Increased levels of uremic toxins cause thrombogenicity by increasing tissue factor (TF) expression and activating the extrinsic coagulation cascade. TF is induced in monocyt
Growth differentiation factor 11 (GDF11 or bone morphogenetic protein 11, BMP11) belongs to the transforming growth factor-β superfamily and is closely related to other family member—myostatin (also known as GDF8). GDF11 was firstly identified in 2004 due to its ability to rejuvenate the func...
Vyse, T.J., Walport, M.J. (1994). The Complement System and Connective Tissue Disease. In: Panayi, G.S. (eds) Immunology of the Connective Tissue Diseases. Immunology and Medicine Series, vol 22. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1432-5_7 ...
Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic m