Tissue factor (TF) is a protein that plays a critical role in blood clotting, but recent research has also shown its involvement in cancer development and progression. Herein, we provide an overview of the structure of TF and its involvement in signaling pathways that promote cancer cell prolife...
Importantly, it was demonstrated that adsorption of fibrinogen is a critical factor stimulating biomaterial-induced inflammation at the implantation area [60,104,[114], [115], [116], [117]]. Fibrinogen binds to the implant surface via D domain that further undergoes conformational changes exposing...
Tissue factor (TF), also known as coagulation factor III, is a transmembrane single-chain glycoprotein with 263 amino acid residues. The physiological role of TF is to initiate extrinsic coagulation cascade when the tissue is injured [10]. Although TF is critical for normal hemostatic functions, ...
It is poorly understood how different cells in a tissue organize themselves to support tissue functions. We describe the CytoCommunity algorithm for the identification of tissue cellular neighborhoods (TCNs) based on cell phenotypes and their spatial dis
insulin-like growth factor, contribute to mammary tumorigenesis [6]. On the other hand, an inverse correlation is reported between obesity and adiponectin, for which low levels of adiponectin constitute a risk factor for mammary cancer [7]. Nevertheless, data on adiponectin actions in breast cancer...
However, neutrophile-like inflammatory cells and monocyte-like cells are accumulated in growth factor-stimulated CAM which may participate in the wound healing process[9]. Kilarski et al. [10] have developed a method to investigate GT formation in the CAM. This model has allowed a better ...
a Heatmaps representing the enrichment of transcription factor binding motifs for brain and blood tsDMRs the orthologous regions of these tsDMRs. Left panel: motif enrichment for rat-mouse comparison; right panel: motif enrichment for rat-human comparison. b Motif enrichment (fold change) of the...
Yet, as quantifying just a single cell population is demanding, little is known about how all these cell populations collectively predict the prognosis of cancer patients. The ability to simultaneously quantify multiple cell populations within a tissue sample thus appears critical to identify clinically...
Thus, it is difficult to remove these slow components of lipids completely using SDS-based ETC methods, and extended ETC (>24 hr) might cause tissue damage. Therefore, these would serve as a limiting factor for thicker tissue clearing using the ACT protocol. It should also be noted that ...
{h}\)region in Supplementary Fig.35A. Here, we used UMAP-reduced cellular context representation and mapped it to the CIELAB color space for each cell to illustrate these variations. The second factor is the Leiden clustering resolution. When we increased the clustering resolution, we observed ...