靶向Tissue Factor的ADC药物TIVDAK获美国FDA完全批准 OnApril 29th, 2024, the U.S. FDA granted full approval for Seagen Inc.'s TIVDAK®(tisotumab vedotin) targetingtissue factor (TF)for the treatment of patients with recurrent or metastatic cervical cancer who have progressed on or after chemoth...
A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.Ke Yu...
In a mouse xenograft of human pancreatic tumor cells, XB002 was found to be stronger than an ADC containing monomethyl auristatin E (MMAE) conjugated to the same anti–tissue factor antibody. In patient-derived xenograft models derived from several tumor types, the ADC was found to b...
Tissue factor (TF), also known as coagulation factor III, is a transmembrane single-chain glycoprotein with 263 amino acid residues. The physiological role of TF is to initiate extrinsic coagulation cascade when the tissue is injured [10]. Although TF is critical for normal hemostatic functions, ...
To explore the possibility of using tissue factor as a target for an antibody-drug conjugate (ADC), a panel of human tissue factor–specific antibodies (TF HuMab) was generated. Three tissue factor HuMab, that induced efficient inhibition of TF:FVIIa-dependent intracellular signaling, antibody-...
The present invention discloses a tissue factor antibody targeting - drug conjugate. 本发明还公开了制备所述的抗体药物偶联物(ADC)的方法. The present invention also discloses the preparation of an antibody - drug conjugate (ADC) method. 本发明的ADC能够高特异性地结合TF抗原,其具有很高的亲和力,很低...
Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic m
1 项与tissue factor x ROR1 x Top I 相关的新闻(医药) 2023-11-20 ·生物制药小编 乳腺癌ADC治疗靶点:在HER2、TROP-2之外 乳腺癌是一种常见的恶性肿瘤,治疗方法包括手术、放疗、化疗和靶向治疗等。近年来,ADC药物被广泛用于乳腺癌的治疗中,其中包括了T-DM1、T-DXd和saituzumab govitecan(SG)等药物。这些...
英文名称: Tissue Factor 蛋白, Human (HEK293, Fc) 总访问: 50 国产/进口: 进口 半年访问: 12 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 10 μg; 50 μg 最后更新: 2024-11-4 货号: HY-P7787A CAS 号: 参考报价: 1600; 4500 立即询价 电话咨询 ...
ADC: anchorage-dependent cell. DECHS: DPC/EPC co-cultured hydrogel system. DPC: dermal papilla cell. ECM: extracellular matrix. EPC: epidermal cell. FT-IR: Fourier transform infrared. GAG: glycosaminoglycan. GC: GelMA/chitosan. GelMA: gelatin methacryloyl. HE: hematoxylin-eosin. HF: hair follic...