Müllerian epithelial apoptosis seems to be mediated at least in part by an extracellular proteinase, matrix metalloproteinase 2 (MMP2), a downstream target of AMH/AMHR2 signaling that functions as a paracrine “death factor.”323 Inhibition of MMP2 activity in vitro can prevent AMH-induced duct...
They are more common in middle-aged or older adults, but can also affect children and young adults. Indeed, as a proportion of pediatric malignancies, they comprise 7 to 10% of childhood cancers, and are an important cause of death in the 14 to 29 age group.5,6 ...
cfDNA is released into the bloodstream as a consequence of cellular processes, such as apoptosis, pyroptosis, mitotic catastrophe, autophagy, phagocytosis, or a regulated form of neutrophil cell death referred to as NETosis [4]. The levels of cfDNA are higher in patients with cancer and, consequ...
There was a case of a nasal cavity teratoma in a 10 year old boy with numerous recurrences and eventual death. Conclusions: In our study non-epithelial neoplasms constituted 5% of primary sinonasal tumors, malignant in their majority, often aggressive with multiple recurrences, heterogeneous, with ...
University of Maryland, Baltimore; Maryland Office of the Chief Medical Examiner, Baltimore; University of Maryland School of Medicine, Baltimore. Background: The terminology and classification of sudden cardiac deaths in patients with cardiomegaly as the primary cause of death have not been clarified...
Cancer is the leading cause of death worldwide. Fortunately, the survival rate of cancer continues to rise, owing to advances in cancer treatments. However
Amongst those who underwent an AR, death occurred in 42 patients (23.2%). The 5-year OS and DFS rates were 77.4% (95%CI 73.7–81.1) and 70.1% (95%CI 66.3–73.9) respectively. A LR was diagnosed in nine patients (5.0%), while SR was identified in 34 patients (18.8%). The median...
Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality of life. Scarring and fibrosis prevent proper skin, mucosa and muscle regeneration during woun
Background: Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive sarcoma with a predilection for the deep soft tissues of the extremities and trunk and a propensity for local recurrence, metastasis and tumor-related death. A subset of SEF shows morphologic and molecular overlap with low grade...
Periodontal ligament stem cells regulate B lymphocyte function via programmed cell death protein 1. Stem Cells. 2013;31(7):1371–82. CAS PubMed Google Scholar Li J, Xu SQ, Zhang K, Zhang WJ, Liu HL, Xu Z, et al. Treatment of gingival defects with gingival mesenchymal stem cells ...