今年南京DIA QSF会议后,可能在最新版本ICH E9R绿皮书中tipping point analysis出现的频率比较高,接到了组里的一个任务,研究各种终点的临界值分析方法应用(主要用于缺失数据假设的敏感性分析),这也是目前在处理缺失数据时FDA推荐的敏感性分析方法。目前在阅读了大量文献后,已经整理了关于连续型终点和time to event类型...
Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2012; DOI:10.1056/NEJMoa1207541. Abstract. 0 Cite this: FDA approval of apixaban for stroke prevention in AF: The "tipping point" for novel oral anticoagulants - Medscape - Jan 11, 2013.Comments...
R. Resistant, robust and non-parametric techniques for the analysis of climate data: Theory and examples, including applications to historical radiosonde station data. International Journal of Climatology 61 (1996). 63. Pohlert, T. trend: Non-Parametric Trend Tests and Change-Point Detection, ...
THE SYMPOMATIC TIPPING POINT: FACTORS THAT PROMPT MEN AND WOMEN TO SEEK MEDICAL CARE Aim of the study: The problem of premature ending of therapy is a common phenomenon and is taken under consideration as closely related to effectiveness of... C Kreatsoulas,M Crea-Arsenio,M Giacomini,... ...
According to Malcolm Gladwell, the “tipping point” is “the moment of critical mass, the threshold, the boiling point” where “ideas…spread like viruses do.”1 Organizations originally created by patients and their caregivers have now reached a tipping point in their influence on government an...
4. The three rules of the Tipping Point — the Law of the Few, the Stickiness Factor, the Power of Context — offer a way of making sense of epidemics. They provide us with direction for how to go about reaching a Tipping Point. The balance of this book will take these ideas and ...
In response, many precipitation sensors for point measurements with various operating mechanisms have been developed; e.g., optical sensors, impact sensors, acoustic sensors, and tipping-bucket (TB) rain gauges; the latter are worldwide the most widely used rain collectors [1,18]. In fact, ...