今年南京DIA QSF会议后,可能在最新版本ICH E9R绿皮书中tipping point analysis出现的频率比较高,接到了组里的一个任务,研究各种终点的临界值分析方法应用(主要用于缺失数据假设的敏感性分析),这也是目前在处理缺失数据时FDA推荐的敏感性分析方法。目前在阅读了大量文献后,已经整理了关于连续型终点和time to event类型...
Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2012; DOI:10.1056/NEJMoa1207541. Abstract. 0 Cite this: FDA approval of apixaban for stroke prevention in AF: The "tipping point" for novel oral anticoagulants - Medscape - Jan 11, 2013....
R. Resistant, robust and non-parametric techniques for the analysis of climate data: Theory and examples, including applications to historical radiosonde station data. International Journal of Climatology 61 (1996). 63. Pohlert, T. trend: Non-Parametric Trend Tests and Change-Point Detection, ...
4. The three rules of the Tipping Point — the Law of the Few, the Stickiness Factor, the Power of Context — offer a way of making sense of epidemics. They provide us with direction for how to go about reaching a Tipping Point. The balance of this book will take these ideas and ...
In response, many precipitation sensors for point measurements with various operating mechanisms have been developed; e.g., optical sensors, impact sensors, acoustic sensors, and tipping-bucket (TB) rain gauges; the latter are worldwide the most widely used rain collectors [1,18]. In fact, ...