The timsTOF Pro with PASEF technology delivers revolutionary improvements in scan speed, coupled with enhanced specificity and high sensitivity. It does so while simultaneously maintaining ultra-high resolution for both precursors and MS/MS spectra. This unique performance quintet gives scientists the tools...
您可以不采用折中的办法优化您的LC/MS方法。 全灵敏度的分辨率;无需在灵敏度,分辨率两种模式之间做出选择,从而使您对样品的分析毫无限制。 更宽的动态范围;大大增加了仪器对不同浓度样品的稳定性,这样就可以简化样品预处理过程,尤其是在高通量的定量实验中。 极限的灵敏度;创造性的灵敏度的改善使得compact对痕量...
在 LC-MS/MS分析中, dia-PASEF 能够采集包含 m/z,离子淌度值( CCS ),保留时间和离子强度的 4D 数据。前所未有的蛋白质覆盖深度凭借强大的 SRIG( 不锈钢堆叠环形离子向导 )装置和新优化的 dda-PASEF 方法 ,timsTOF Pro 2 单针能够达到前所未有的蛋白组学覆盖深度。使用自制 HEK 酶切样本, 上样 200 ng,...
The timsTOF Pro 2, powered by PASEF® technology, paves the way to 4D-Proteomics and 4D-Lipidomics.
IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma Wahle, M.; Thielert, M.; Mann, M. et al. Molecular & Cellular Proteomics, 2024, 23, 100689 https://doi.org/10.1016/j.mcpro.2023.100689 Ultra-sensitive metaproteomics (uMetaP) redefines the dark field of metaproteome, enables...
PASEF was his idea, Bruker made his idea to become true with timsTOF Pro. Gary Kruppa, Vice President for Omics Solutions at Bruker Daltonics, said: “Proteomics researchers always want improvements in speed, sensitivity and quantitative capabilities, while maintaining the advantages of high-resolution...
高质量分辨率无助于这些问题的解决,timsTOF fleX 提供了唯一的机会来区分同分异构体的分布。碰撞横截面( CCS )是 TIMS 给出的测量结果,提供了从另一角度来验证质谱分析结果。CCS 关联软件智能地将空间 MALDI-TIMS 成像数据与多组学结果相匹配,并使鉴定结果与重要的形态学内容相关联。
The liquid phase charge of the subunits was determined using the Prot pi Protein Tool (https://www.protpi.ch/Calculator/ProteinTool) using the respective pH of the BGE and the sequence of the subunit. Results CE-MS Subunits can be generated using various reduction approaches. Initially, we ...
timsTOF fleX 建立在布鲁克开创性 timsTOF Pro 平台上,功能齐全、速度快、灵敏度高的 ESI 质谱,可用于所有 X-Omics 分析。结合了高空间分辨率的 MALDI 源和平台机械专业设计,用于解析分子分布和带来组学分析的空间维度。将蛋白质组学分析转换为空间蛋白质组学,将脂质组学转换为空间脂质组学,将代谢组学转换为空间代谢...
Created especially for high resolution MALDI Imaging workflows. The key to success in MALDI MS analyses. Introducing fleXmatrix for MALDI-2 BROCHURE TIMSTOF PRO AND TIMSTOF FLEX Four reasons to switch to 4D-Proteomics? on the timsTOF platform ...