TIMOLOL EYE DROPS: ANOTHER WARNING ABOUT SYSTEMIC EFFECTSInpharma Weekly -doi:10.1007/BF03302484Springer International PublishingInpharma
The case descriptions show that even a low dose of timolol eye drops may cause systemic adverse effects. The authors note that at least 80% of the administered drop drains through the nasolacrimal canal where it is absorbed by the nasal mucosa. Thus, it is absorbed systemically, and the ...
diurnal effectsintraocular pressureblood pressureheart rateplasma concentrationsA comparison of the diurnal effects of timolol 0.5% and metoprolol 3.0% eye drops on the intraocular pressure, blood pressure and heart rate in 10 glaucoma patients was performed in a double-masked cross-over study. Both ...
The concomitant use of beta-adrenergic blocking agents with digitalis and calcium antagonists may have additive effects in prolonging atrioventricular conduction time. CYP2D6 Inhibitors Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment wi...
Cardiovascular responses to metipranolol and timolol eyedrops in healthy volunteers. 1. Intraocular pressure and cardiovascular responses to metipranolol 0.1% and 0.3% and timolol 0.25% eyedrops were measured in a balanced single dose place... PJ Bacon,DJ Brazier,R Smith,... - 《Br J Clin ...
The systemic effect of three β-blocking eyedrops was compared in a placebo-controlled, double-blind trial in 12 healthy male volunteers. Each subject rece... Ivan,Berlin,MD,... - 《Clinical Pharmacology & Therapeutics》 被引量: 36发表: 1987年 The short-term effect of adding brimonidine 0.2...
Systemic bioavailability and cardiopulmonary effects of 0.5% timolol eyedrops Background. To investigate the pharmacological basis of systemic side effects of ophthalmic timolol, we estimated the systemic bioavailability of 0.5% tim... JM Korte,T Kaila,MK Saari - 《Graefes Archive for Clinical & ...
There is relatively high incidence of the cardiovascular and respiratory side-effects which is a major drawback for timolol eye drops [136], due to these side-effects only 1–2% of the instilled dose penetrates the eye, whilst the majority of the dose reaches the systemic circulation [137]....
in heart rate and hence arterial pulse (via systemic absorption) reduces correspondingly the higher frequency components of the microfluctuations.The effects of timolol and betaxolol on within-task measures of accommodative response have shown... B Gilmartin - Birkhäuser Basel 被引量: 6发表: 2000...
Topical and systemic pre-treatment with GLC756 and timolol resulted in reduced cell infiltration in the eye. In addition, GLC756 reduced, whereas timolol increased the incidence of arthritis. Betamethasone suppressed almost completely the cell infiltration in the eye and the incidence of arthritis. ...