Rate of Loss of eGFR and Time-Averaged Proteinuria in IgA Nephropathy (IgAN) Patients Progressing from Early-Stage Disease to Kidney Failuredoi:10.1681/ASN.20233411S1995aDavid PitcherRenal Registry, Bristol, United Kingdom;Fiona E. Braddon
Methods: Altogether 1,327 patients with diabetes and without kidney disease (estimated glomerular filtration rate [eGFR]≥60 ml/min/1.73m2 , and without proteinuria) were included. Incident DKD were defined by the occurrence of renal function decline (eGFR<60 ml/min/1.73m2 ) and/or macro...
Results. Patients with high TA-SUA levels had higher levels of baseline SUA, blood urea nitrogen (BUN), triglycerides, serum C3 and serum C4 and were more likely to be male and have hypertension, proteinuria, poor renal function, and pathological injuries including high grades of tub...
(9.9%) reached the primary outcome of ESRD and 19 patients (12.5%) reached the combined renal endpoint. Kaplan-Meier analysis showed that the persistent hematuria group had a lower renal survival rate. The persistent hematuria patients who were incorporated with proteinuria (≥1.0 g/day) and ...