T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-纬-producing CD4+ and CD8+ T cells. Initial data in
参考文献：[1] 陶景莲, 李丽娟, 邵宗鸿. TIM3在肿瘤微环境中作用的研究进展[J]. 中国免疫学杂志, 2016, 32(7):1070-1073.[2] Wolf Y, Anderson A C, Kuchroo V K. TIM3 comes of age as an inhibitory receptor[J]. Nature Reviews Immunology, 2019: 1-13.
TIM-1是哮喘和变态反应的重要易感基因，它优先在T-helper 2（Th2）细胞上表达，并起着有效刺激T细胞活化的共刺激分子的作用。TIM-3优先在Th1和Tc1细胞上表达，并产生抑制信号，导致Th1和Tc1细胞凋亡；TIM-3也表达在某些树突状细胞上，可以介导凋亡细胞的吞噬作用和抗原的交叉呈递。TIM-4仅在抗原呈递细胞上表达，...
[1]Monney, L. et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature (2002) [2]Yochai Wolf et al. TIM3 comes of age as an inhibitory receptor. Nature Reviews Immunology (2019). [3]Chiba, S. et al. Tumor-infiltrating...
Kuchroo, TIM3 comes of age as an inhibitory receptor. Nat Rev Immunol, 2020. 20(3): p. 173-185. TIM3靶点相关模型列表 百奥动物 立足全球生物医药行业,从技术创新出发,百奥赛图建立“BioMice百奥动物”子品牌。百奥动物集创新动物模型研发制备、生产供应和实验服务为一体,拥有2500余个独特基因编辑动物/...
[2] Wolf, Y., A.C. Anderson, and V.K. Kuchroo,TIM3 comes of age as an inhibitory receptor.Nat Rev Immunol, 2020.20(3): p. 173-185. TIM3靶点相关模型列表 百奥动物 立足全球生物医药行业,从技术创新出发,百奥赛图...
1. Wolf, Y., Anderson,A. C. & Kuchroo, V. K. TIM3 comes of age as an inhibitory receptor.Nat.Rev. Immunol. 20, 173–185 (2020). 2. Lee, J. et al.Phosphotyrosine-dependent coupling of Tim-3 to T-cell recep...
[2] 药融云数据库 https://www.pharnexcloud.com/?zmt-mhwz [3]TIM3 comes of age as an inhibitory receptor |Nature Reviews Immunology [4] https://www.astrazeneca.com/our-therapy-areas/pipeline.html 想要解锁更多药企创新药研发信息吗?查询药融云数据库(https://www.pharnexcloud.com/?zmt-mhwz)掌...
参考来源: [1] CDE官网 [2]TIM3 comes of age as an inhibitory receptor |Nature Reviews Immunology [3] https://www.astrazeneca.com/our-therapy-areas/pipeline.html
目前全球研发TIM3PD1双特异性抗体的公司不多,据药融云数据显示,研究进入临床试验的只有阿斯利康和罗氏,其余皆处于临床前或者研究终止,国内仅有一家健信生物在研。 参考来源: [1] CDE官网 [2]TIM3 comes of age as an inhibitory receptor |Nature Reviews Immunology [3]网页链接 $阿斯利康(AZN)$...