TIM3可降低肿瘤cDC1s分泌CXCL9,并间接抑制CD8+T细胞的细胞毒性;在NK细胞中表达时,TIM3被认为可能是功能障碍的NK细胞的标志物,TIM3阻断已被证明可逆转NK细胞的功能障碍[11];在肥大细胞中表达时,TIM3被证明具有激活这类细胞的功能,这与它在其它免疫细胞中的抑制作用相反。
TIM3可降低肿瘤cDC1s分泌CXCL9,并间接抑制CD8+T细胞的细胞毒性;在NK细胞中表达时,TIM3被认为可能是功能障碍的NK细胞的标志物,TIM3阻断已被证明可逆转NK细胞的功能障碍[11];在肥大细胞中表达时,TIM3被证明具有激活这类细胞的功能,这与它在其它免疫细胞中的抑制作用...
TIM-3 在 CD4+TH1 辅助 T 细胞和 CD8+Tc1 细胞毒性 T 细胞上表达,并在具有增强抑制功能的 Treg 细胞亚群上组成性表达。TIM-3 也可由天然免疫细胞如 DC、NK 细胞、单核细胞和巨噬细胞上表达3。它在高度功能失调的 T 细胞上表达,并与多种癌症的不良...
Our team previously found that overactive MDSCs and exhausted TIM3 CD8 T cells were observed in myelodysplastic syndromes (MDS) patients. However, it is not obvious whether MDSCs suppress CD8 T cells through TIM3/Gal‐9 pathway. Here, Gal‐9, as the ligand of TIM3, was overexpressed in ...
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-纬-producing CD4+ and CD8+ T cells. Initial data indicated that TIM3 functioned as a 'co-inhibitory' or 'checkpoint' receptor, but...
Fig2. Analysis of hTIM3 expression on stimulated CD4+ and CD8+ T cells in hTIM-3 knockin mice by FACS. (Completed in cooperation with CrownBio) Fig3. Analysis of hTIM3 expression at very low levels on naive T cells by FACS.
cellimmunoglobinmucin3(Tim3)inCD4andCD8Tcellsanditssignificance.Methods:Pe. ripheralbloodsampleswereobtainedfrom6healthyvolunteers.Lymphocyteswereisolated andstimu— latedwithPHA.Then,theLymphocytesweredividedintosinglefactorgroups(groupsCsA, MMF, FK506,RAPA,andDMX)andcombinedinterventiongroups(groupCI)andexpos...
on tumour-associated DCs than on tumour-infiltrating CD8+T cells. TIM3 induction on immature bone marrow-derived DCs co-cultured with mouse tumour cell lines was synergistically prevented by the blockade of vascular endothelial growth factor receptor 2 (VEGFR2), interleukin-10 (IL-10) and arginase...
cells[J].AIDS Res Hum Retroviruses,201 1,27(1):1-3. 【13]Sakhdari A1,Mujib S,Vali B,etal.Tim-3 negatively regulates cytotoxicity in exhausted CD8+T cells in HIV infection[J].Lichterfeld M,ed.PLoS ONE,2012;7(7):e40146.doi:10. ...
The CD8+CD103+ Trm subgroups were also age‐related predictors for survival in GB. 展开 关键词: age disease outcome glioblastoma PD1 predictors TIM3 tissue‐resident memory T cells (Trm) DOI: 10.1111/imm.13710 年份: 2024 收藏 引用 批量引用 报错 分享 ...