Demishtein-Zohary, K., M. Marom, W. Neupert, D. Mokranjac, and A. Azem. 2015. GxxxG motifs hold the TIM23 complex together. FEBS J. 282:2178-2186. http://dx.doi.org/10.1111/febs.13266
论文 论文标题:Structural basis of mitochondrial protein import by the TIM23 complex 作者:Sim, Sue Im, Chen, Yuanyuan, Lynch, Diane L., Gumbart, James C., Park, Eunyong 期刊:Nature 发表时间:2023/06/21 数字识别码:10.1038/s41586-023-06239-6 摘要:Mitochondria import nearly all of their ap...
Among about ten different subunits of the TIM23 complex, the essential multipass membrane protein Tim23, together with the evolutionarily related protein Tim17, has long been postulated to form a protein-conducting channel6,7,8,9,10,11. However, the mechanism by which these subunits form a ...
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. 应用类型 WB 免疫原 TIMM23 来源宿主 兔 反应性 人 保存建议 建议收到该Mitochondrial Import Inner Membrane Translocase Subunit Tim23 (TIMM23)...
GxxxG Motifs - The Glue That Holds the TIM23 ComplexKeren DemishteinZohary
Tim23 together with Tim17 and Tim44 form the Tim23 complex which mediates the import of nuclear encoded preproteins into the mitochondria. Tim23 is commonly used as loading control for mitochondrial inner membrane protein. 实验方案 Product Specific Protocols IF protocol for CL Plus 488 Tim23 ...
The TIM23 complex is a hub for translocation of preproteins into or across the mitochondrial inner membrane. This dual sorting mechanism is currently being investigated, and in yeast appears to be regulated by a recently discovered subunit, the Mgr2 protein. Deletion of Mgr2p has been found to...
The presequence translocase of the mitochondrial inner membrane (TIM23 complex) facilitates anterograde precursor transport into the matrix and lateral release of precursors with stop-transfer signal into the membrane (sorting). Sorting requires precurso
Accordingly, for the handover of the precursor from TOM to the TIM23 complex, both complexes need to be in proximity to each other. A complex set of protein interactions among IMS-domains of Tom22, Tim50, Tim23, and Tim21 and with the presequence of the incoming precursor are thought ...
The preprotein translocase of the inner membrane of mitochondria (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane. ... Mokranjac,D. - 《Embo Journal》 被引量: 114发表: 2014年 Structural changes in the mitochondrial Tim23 channel are coupled to the ...