TIM-3是TIM家族的一个受体蛋白,在T细胞、Treg细胞、先天免疫细胞(树突细胞、自然杀伤细胞、单核细胞)表面表达。此前,诺华认为sabatolimab可通过抑制TIM-3受体的功能,进而起到同时靶向髓系白血病细胞和免疫细胞的作用,不但可以杀伤癌细胞,还可能增强免疫细胞的活力。 作为TIM-3赛道的领头羊,sabatolimab此次的III期研...
机械分析显示,Tim-AIII-HSP90复合物进一步靶向并降解谷胱甘肽过氧化物酶4(GPX4),并促进GPX4的泛素化,如免疫沉淀、降解和体外泛素化测定所示。此外,当HSP90 shRNA转染敲低HSP90时,Tim AIII抑制细胞增殖,诱导细胞死亡,导致ROS和铁积累,MDA产生,GSH耗竭,以及GPX4泛素化和降解显著消除。重要的是,Tim AIII在皮下异种...
Firefly III: a personal finances manager. Contribute to BuchholzTim/firefly-iii development by creating an account on GitHub.
Firefly III: a personal finances manager. Contribute to timhae/firefly-iii development by creating an account on GitHub.
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These complexes showed greatly enhanced emission intensity while embedded in a PMMA(polymethyl methacrylate) matrix film. The amplified quantum efficiency, improved phosphorescence lifetime, and enhanced porous network of M2-PMMA composite helps to improve the sesitivity of TNT vapor detection. ...
产品: 激光扫描仪传感器TiM 激光等级: 1 (IEC 60825-1:2014, EN 60825-1:2014) 应用领域: Indoor 光源: 红外线 (850 nm) 销售: 全国 数量: 999 安全相关的工作区域: 0.05 m ... 5 m (反射比为 5% 时) 扫描区域平整度: ± 1.5° 工作区域: 0.05 m ... 25 m (反射比 > 90% ...
III.根据短文内容,从短文后所给的选项中,选出能填入空白处的最佳选项。选项中有两项为多余选项。(根据课本P782b改编)I'm having a great time on my student exchange program in France. 6 They go out of their way to make me feel at home. The grandm a knows that I miss Chinese food very ...
III. 阅读理解(20分)A Special:Chicken Price:40 yuan/person Haohao Restaurant Opening time:10:30-23:00Address: No. 81 South Street Tel:640-6564Special:Fish Price:60 yuan/person Zhuyu Restaurant Opening time:11:00-22:00Address: No. 54 Dongcheng Road Tel:652-2263Special:Beef Price:55 yuan...
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