Tight junction and gap junction are major cell junctions that play important roles in cellular communication and structural integrity. Alterations of these junctions are known to be involved in cancer pathogenesis. Claudins and connexins are major tight and gap junction proteins, but genetic alterations...
Compare/contrast the structure and function of tight junction, desmosomes, gap junction, and plasmodesmata.Cell junctionsEvery living being is built from cells, similar to the way an office building is made up of different rooms. If every room was isolated, t...
The manner of shutting; the union of parts; junction. Close (sales) The point at the end of a sales pitch when the consumer is asked to buy. Close A grapple in wrestling. Close (music) The conclusion of a strain of music; cadence. Close (music) A double bar marking the end. Close...
ZO-1 associates to the adherens junction proteins α-catenin (Itoh et al., 1997) and to the gap junction proteins connexins 43 (Barker et al., 2002; Toyofuku et al., 1998) and 45 (Kausalya et al., 2001). ZO-1 is a phosphoprotein, however the effect of phosphorylation will remain ...
GAP JUNCTION A junction between two cells consisting of pores that allow passage of molecules (up to 9 kDa). PDZ DOMAIN Protein–protein interaction domain first described in the proteins PSD-95, DLG and ZO-1. POSTSYNAPTIC DENSITY Higher-order protein structure present in postsynaptic membranes th...
Claudin family tight junction proteins form charge- and size-selective paracellular channels that regulate epithelial barrier function. In the gastrointestinal tract, barrier heterogeneity is attributed to differential claudin expression. Here, we show that claudin-23 (CLDN23) is enriched in luminal intes...
Our observations suggest, for the first time, that increased expression of tight junction proteins may be one of the mechanisms by which Misoprostol induces CR in humans. Further studies are needed to explore if TJ proteins may be therapeutic targets to alter timing of CR in clinical practice.Ba...
Our observations suggest, for the first time, that increased expression of tight junction proteins may be one of the mechanisms by which Misoprostol induces CR in humans. Further studies are needed to explore if TJ proteins may be therapeutic targets to alter timing of CR in clinical practice. ...
ARTICLE Received 29 Oct 2015 | Accepted 9 May 2016 | Published 23 Jun 2016 DOI: 10.1038/ncomms11876 OPEN Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier Yvan Campos1, Xiaohui Qiu1, Elida Gomero1, Randall Wakefield2, ...
Claudin-2 is a tight junction protein that mediates paracellular water transport in intestinal epithelia, rendering them "leaky". Using whole body VDR-/- mice, intestinal epithelial VDR conditional knockout (VDRΔIEC) mice, and cultured human intestinal epithelial cells, we demonstrate here that ...