Tight junctions play a critical role in tubular function. In mammalian kidney, the transepithelial electrical resistance and the complexity of the tight junction increase from the proximal to the collecting tubule. The differential expression of three tight junction proteins, ZO-1, ZO-2, and ...
Tight junction proteins, such as occludin and claudin family members, are transmembrane proteins. Their role in the formation and function of tight junction has been firmly established [18,19]. However, it has been shown that these molecules also have the ability to mediate cell–cell adhesion ...
J. Depletion of Caco-2 cell cholesterol disrupts barrier function by altering the detergent solubility and distribution of specific tight-junction proteins. Biochem. J. 387, 553–560 (2005). CAS PubMed PubMed Central Google Scholar Lynch, R. D. et al. Cholesterol depletion alters detergent-...
Although tight junction proteins are critical to maintain liver function, it is unknown whether they modulate the hepatic circadian clock. In this study, we demonstrated that tight junction protein 1 (TJP1) functions as a mediator of mTOR to modulate the hepatic circadian clock. Mechanistically, ...
Tight junctions and tight junction proteins in mammalian epidermis. 机译:哺乳动物表皮中的紧密连接和紧密连接蛋白。 获取原文 获取原文并翻译 | 示例页面导航 摘要 著录项 相似文献 相关主题 摘要 Tight junctions (TJ) are barrier forming cell-cell junctions that are found in a variety of cell types...
Fluids Barriers CNS (2021) 18:7 https://doi.org/10.1186/s12987-021-00240-9RESEARCHCirculating tight-junction proteins are potential biomarkers for blood–brain barrier function in a model of neonatal hypoxic/ischemic brain injuryE. Axel Andersson , Carina Mallard and C. Joakim Ek *Abstract Back...
Subcellular location Cell membrane, Cell junction Applications IHC/IF Human, Mouse, Rat 1: 500-1: 1200 colon, duodenum, small intestine Background Tjp1, TjpP2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhes...
This was paralleled by maintained gene expression of tight junction proteins that promote integrity of the leak pathway. While these data are in line with evidence that small bowel resection induces tightening of the paracellular barrier [54], they are appar- ently in contrast to evidence that ...
Tight junction barrier defects allow bacterial products/enterotox- ins and dietary and luminal antigens to cross the IE and enter the lamina propria. If the foreign substances are taken up by antigen- presenting cells (APC), APC and Th1 cells can release tumor ...
Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult J. Mol. Neurosci., 44 (2) (2011), pp. 130-139 Google Scholar [84] P. Liu, R. Zhang, D. Liu, J. Wang, C. Yuan, X. Zhao, Y. Li, X. Ji...