The major aims of this study were to determine the effect of IL-1 on intestinal epithelial TJ permeability and to elucidate the intra- cellular mechanisms involved in the IL-1 effect, using a well- established in vitro intestinal epithelial model system consisting of filter-grown Caco-2 ...
1976 . Effect of plant cytokinins on microfilaments and tight junction permeability . Nature 264 ( 5587 ): 666 – 668 .Bentzel, C. J.; Hainau, B.; Edelman, A., et al. Effect of plant cytokinins on microfilaments and tight junction permeability. Nature 264:666–668; 1976. View ...
et al. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical–basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J. Cell Biol. 134, 1031–1049 (1996). CAS PubMed Google Scholar ...
Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. J Pharmacol Exp Ther, 284 (1998), pp. 362-369 View PDFView articleView in ScopusGoogle Scholar 94. Usami M, Komurasaki T, Hanada A, Kinoshita K, Ohata A Effect...
tight junctions formed by the fusion of integral proteins of the lateral cell membranes of adjacent epithelial cells, limiting transepithelial permeability. Synonym(s): impermeable junction, tight junction Farlex Partner Medical Dictionary © Farlex 2012 tight junc·tion (tīt jŭngk'shŭn) An in...
Freeze-fracture of acinar cells shows that the number of tight junctional strands and the tight junction depth are slightly decreased upon carbachol stimulation. The findings suggest that cholinergic stimulation of the exocrine pancreas increases the permeability of the acinar cell junctions to moderately...
A high-fat diet may impair mucus production and decrease expression of the tight junction proteins, contributing to greater intestinal permeability. What You Need to Know About Leaky Gut and Diet Both Occludin and ZO-1, the two key protein components of the tight junction, are downstream to TNF...
Bisphosphonates increase tight junction permeability in the human intestinal epithelial (Caco-2) model 来自 Elsevier 喜欢 0 阅读量: 32 作者:Xavier,Boulenc,and,Claude,Roques,and,Henri,Joyeux,and,Yves,Berger,and,Gérard,Fabre 摘要: The human Caco-2 monolayer model was used to elucidate the ...
The present article investigates the role of cell cytoskeleton on tight junction permeability in the cornea by combined methods based on microscopy and electrophysiology. Ultrastructural characterization of the cytoskeletal network of the cornea was performed using the S-1 myosin subfragment labeling techniq...
Here, we identify a 28-amino-acid sequence in the TJ adaptor protein ZO-1, which is responsible for actin binding, and show that this interaction is essential for TJ permeability. In contrast to the strong interactions at the adherens junction, we find that the affinity between ZO-1 and ...