cre鼠就是我们常用的带有不同的cre酶的工具鼠统称,可用于繁育交配,比如说B6.129P2-Lyz2 tm1(cre)lfo/NJU, 这种就是我们的带有骨髓细胞特异表达cre酶的模型,还有很多很多在不同组织表达的酶的模型,可以根据自己的实验需求来安排。 Tie2-cre/ERT2(Tek-cre/ERT2)小鼠介绍 内皮细胞诱导型特异表达cre,与带有两个...
However, interestingly, we observed strong and uniform lacZ expression in mesenchymal cells of the atrioventricular canal of Tie2-Cre;CAG-CAT-Z double-transgenic mice. We also detected lacZ expression in the mesenchymal cells in part of the proximal cardiac outflow tract, but not in the ...
Tie2-Cre–Induced Inactivation of a Conditional Mutant Nf1 Allele in Mouse Results in a Myeloproliferative Disorder that Models Juvenile Myelomonocytic Leukemia AARON D. GITLER, YI KONG, JOHN K. CHOI, YUAN ZHU, WARREN S. PEAR, AND JONATHAN A. EPSTEIN Departments of Medicine and Cell and ...
Tie2-Cre transgenic mice express Cre recombinase in all endothelial cells. Here, we show that Tie2-Cre-mediated deletion of Nf1 also leads to excision of Nf1 in the hematopoietic lineage. Surviving mice exhibit a myeloproliferative disorder similar to juvenile myelomonocytic leukemia seen in NF1 ...
Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol. 2009; 325 :82–93.Zhang Y, Singh MK, Degenhardt KR, Lu MM, Bennett J, Yoshida Y, et al. Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and ...
cardiacoutflowtractidentifiedcontributionsinpartfromthecardiacneuralcrest.Tie2-Cretransgenicmiceareanew genetictoolfortheanalysesofendothelialcell-lineageandendothelialcell–specificgenetargeting.©2001AcademicPress KeyWords:endocardialcushion;atrioventricularcanal;cardiacoutflowtract;Cre-loxP. INTRODUCTION Fo...
DNA damage response of Tie2-Cre;R26StopFLBmi1 HSCs.DNA damage response of Tie2-Cre;R26StopFLBmi1 HSCs.Shunsuke, NakamuraMotohiko, OshimaJin, YuanAtsunori, SarayaSatoru, MiyagiTakaaki, KonumaSatoshi, YamazakiMitsujiro, OsawaHiromitsu, NakauchiHaruhiko...
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis Similar findings were obtained with Arg1(flox/flox);Tie2cre mice, which delete Arg1 in all macrophage populations. Production of Th2 cytokines increased ... JT Pesce,TR Ramalingam,MM Mentink-Kane,... - 《...
我们采用了Cre-lox P重组酶系统介导的在海马颗粒细胞中特异性敲除Neuritin基因的技术以及在Prox1-Cre小鼠海马DG区注射Cre依赖的Neuritin过表达病毒的手段从正反两方面... 黄青芸 - 《广西医科大学》 被引量: 0发表: 2020年 长枝木霉SMF2 peptaibols合成酶和蛋白酶基因敲除体系的构建及其peptaibols在植物生长中的功...
本课题组先前的研究发现,在胚胎中期利用 Prox1-CreERT2 转基因小鼠介导 Tie2 基因敲除导致小鼠发生水肿。为进一步探究该表型是否与心脏发育有关,本研究利用 Prox1-CreERT2 转基因小鼠、靶向Tie2 的条件性基因敲除小鼠,并结合ROSA26-mT/mG 报 告基因小鼠模型,研究Tie2 敲除对于小鼠心脏与心血管发育的影响。 结果...