分子式:C30H32ClN7O2分子量:558.07 简介:THZ531是CDK12和CDK13的选择性抑制剂,IC50值分别为158 nM和69 nM。 物理性状及指标: 外观:………粉末 溶解性:………H2O :Insoluble;Ethanol:100 mg/mL (179.19 mM);DMSO: 100 mg/mL (179.19 mM) 含量:………>98% 储存...
In VitroThe results from Kinase assays demonstrate that THZ531 potently inhibits CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively; whereas inhibition of CDK7 and CDK9 is more than 50-fold weaker with IC50s of 8.5 and 10.5 μM, respectively. THZ531 treatment leads to a dram...
THZ531;CPD1594;THZ-531;CS-2763;THZ531, 10 mM in DMSO;THZ531; THZ-531; THZ 531;THZ 531,inhibit,CDK,THZ-531,Cyclin dependent kinase,Inhibitor,THZ531;(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide;(...
THZ531 是一种选择性抑制剂,针对CDK12和CDK13的半数抑制浓度(IC50)分别为158 nM和69 nM。 产品性质 英文别名 (English Synonym) THZ531 中文名称 (Chinese Name) / 靶点 (Target) CDK12,CDK13 通路 (Pathway) Cell Cycle/DNA Damage CAS号 (CAS NO.) 1702809-17-3 分子式 (Formula) C30H32ClN...
In Vitro: The results from Kinase assays demonstrate that THZ531 potently inhibits CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively; whereas inhibition of CDK7 and CDK9 is more than 50-fold weaker with IC50s of 8.5 and 10.5 μM, respectively. THZ531 treatment leads to a ...
CDK12-IN-2 货号:BCP46385 CAS号:2244987-03-7 产品详情 CDK4/6-IN-6 货号:BCP46270 CAS号:2380321-51-5 产品详情 CDK5-IN-3 货号:BCP46220 CAS号:2639542-32-6 产品详情 KB-0742 hydrochloride 货号:BCP36919 CAS号:2416874-75-2 产品详情 ...
英文名THZ-531 中文别名 英文别名THZ531; THZ 531; 分子式C30H32ClN7O2分子量558.08 用途 生物活性THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. Cyclin-dependent kinases 12 and 13 (CDK12 and CDK13) play critical roles in the regulation of gene transcription. THZ531 irreversibly targets...