Thyroid Hormone Transport Proteins: Thyroxine-Binding Globulin, Transthyretin, and Albumin☆ Thyroxine-Binding Globulin TBGis a 54kDa acidicglycoproteinsynthesized by the liver (seeTable 1). The mature molecule, minus the 20amino acidssignal peptide, is composed of a singlepolypeptide chainof...
The concentration of thyroxine-binding globulin (TBG) in the serum can now be measured by direct assays that are simple and inexpensive. Comparison of a direct measurement of TBG concentration with a widely used indirect method (Thyopac-3) showed that the indirect method was inaccurate when TBG...
Quick view Sex Hormone Binding Globulin (SHBG) Quick view Immunoglobulin G, Rabbit; ≥99% pure Quick view Immunoglobulin G, Rabbit; ≥95% pure Quick view Luteinizing Hormone, Human (hLH); ≥98% pure Quick view Prostate Specific Antigen (PSA), Non-Complexing; ≥98% pure 6838...
(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine; Tetraiodothyronine; Thryroxine, l-; THX; Thyrax; thyroxin; thyroxinal; Thyroxine; Thyroxine (VAN); Thyroxine, L-; Thyroxine, L- (8CI); thyroxine-binding globulin; transthyretin; β-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)...
Computer analysis of the binding data revealed the presence of two saturable systems with K d values of 3.9 and 29.1 nM and binding capacities of 1.7 and 8.7 pmol/mg of cytosol protein, respectively; a third binding system was non-saturable. The binding of the iodothyronines to the cytosol ...
Precision of the CLIA Kit for Thyroxine Binding Globulin (TBG) Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Thyroxine Binding Globulin (TBG) were tested 20 times on one plate, respectively. ...
Serum free thyroxine (FT4) and thyroid hormone-binding protein concentrations were measured in pregnant women, stilboestrol-treated patients, and subjects with congenital thyroxine-binding-globulin (TBG) excess. In pregnant and stilboestrol-treated patients matched for TBG concentrations, serum FT4 con...
alterations in the serum-binding proteins (particularly thyroxine-binding globulin-TBG) may cause corresponding alterations in the total T4concentration (Fig. 3.1). In these situations, the free T4(FT4) concentration remains normal, and clinical status does not correlate with total T4levels, since on...
Current free T4immunoassaymethodology has been specifically engineered to overcome commonthyroxine binding globulinabnormalities. As a result, these tests include proprietary blockers and binders that make them subject to albumin sensitivity, decreasing diagnostic accuracy under conditions in which there are ...
TBG--thyroxine binding globulin T4--L-thyroxine T4*--L-thyroxine125I DETAILED DESCRIPTION OF THE INVENTION While this invention is satisfied by embodiments in many different forms, there will herein be described in detail a preferred embodiment of the invention, with the understanding that the pres...