Druggable targets For the 112 genes supported by ≥2 criteria, we surveyed gene-drug interactions using the Drug Gene Interaction Database (DGIDB). The protein products of these genes include targets for treatments to stimulate (thyrotropin [TSH]) or suppress (methimazole, targeting thyroid peroxida...
mainly anti-thyroid peroxidase and antithyroglobulin antibodies. Fine- needle aspiration should be used to get a biopsy, when thyroid lymphoma is suspected.
Hashimoto thyroiditis is a primary cause of hypothyroidism and is diagnosed by a decreased T4 and elevated TSH with antibodies against thyroperoxidase (TPO).[16] [1] Charlick M, M Das J. Anatomy, Head and Neck: Internal Carotid Arteries. StatPearls. 2023 Jan:():[PubMed PMID: 32310521] [...
Antibodies to the Thyroperoxidase enzyme prevent it from functioning properly, resulting in decreased or absent ability to iodinate the thyroglobulin. This is called “inability to organify iodine”, and explains the low iodine content of the thyroid gland in Hashimotos patients, and the rapid was...