Thyroid hormones (TH) mediate several critical physiological processes including organ development, cell differentiation, metabolism and cell growth and maintenance. Accumulating evidence has revealed dysregulation of cellular TH activity as the underlying cause of several liver-related diseases, including alcoh...
We therefore propose that thyroid hormones are involved in the homeostatic control of calcium metabolism by potentiating the effects of calcilriol in its classic target organs, intestine and bone.doi:10.1007/978-3-642-83977-1_40H. S. Cross...
7.2Thyroid hormones Thyroid hormones were first used in the treatment of obesity in the 1890s. Despite increasing energy expenditure, thyroid hormones cause insulin resistance andimpaired glucose tolerance, as well as cardiac stimulation, loss of skeletal muscle, bone wasting, fatigue and...
Thyroid hormones act at target organs throughout the body to regulate cellular metabolism. T3and T4also feed back at the brain and anterior pituitary gland to regulate levels of TRH and TSH, respectively. The thyroid hormone axis is a classical negative feedback loop, as thyroid hormo...
αvβ3 Integrin as a Link between the Development of Fibrosis and Thyroid Hormones in Systemic Sclerosis Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. Key players mediating fibrosis are myofibrobla... MY Kohon,M Zaaroor Levy,T Horn...
The nonthyroidal illness syndrome (NTIS) comprises a constellation of alterations in the central component of the HPT axis and changes in thyroid hormones (TH) metabolism in a variety of TH target organs [78]. NTIS can occur in several acute or chronic systemic diseases including cardiovascular,...
Similar to PPARs, tissue-dependent distribution of TR isoforms regulates thyroid hormone actions in target organs. Both TRα and TRβ are expressed in virtually all tissues but the abundance varies for each isoform (Lazar 1993). TRα1 is abundantly expressed in the skeletal muscle, heart, and...
The endocrine system is a complex network of organs and glands that produce various hormones to regulate the function of all the organs in your body. One of the most important hormones is thyroid stimulating hormone (TSH). TSH is a hormone produced by the pituitary gland that tells the thyroi...
Thyroid hormones have vital roles in development, growth and energy metabolism. Within the past two decades, disturbances in thyroid hormone action have been implicated in ageing and the development of age-related diseases. This Review will consider results from biomedical studies that have identified ...
206 As implied above, the high levels of D3 in the pregnant uterus and subsequently in the placenta do not result in a complete barrier to the transfer of maternal thyroid hormones to the fetus, as evidenced by the finding of significant levels of T4 and T3 at term in the serum of a...