In conclusion, the results of our study highlight the crucial role of the maternal thyroid hormone signaling pathway in normal embryonic development, and the adverse effects of nitrate on the expression levels of mRNA related to thyroid hormone signaling pathway and oxidative stress in B. gargari...
Vitamin D receptors (VDR) are present in the cells of the pituitary, the pea-sized gland located at the base of the brain that controls your thyroid. The pituitary produces a hormone called thyroid stimulating hormone (TSH) that signals your thyroid gland to make thyroid hormone (T3 and T4)...
et al. Thyroid hormone receptor and ERRalpha coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Science signaling 11, https://doi.org/10.1126/scisignal.aam5855 (2018). Singh, B. K. et al. FoxO1 deacetylation regulates thyroid hormone-induced transcription of key ...
Y. Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor. Proc. Natl Acad. Sci. USA 103, 1780–1785 (2006). This study demonstrates robust activation of the PI3K–AKT pathway by a mutant thyroid hormone β-receptor that causes FTC in mice, thus ...
Thyroid hormone synthesistakes place at the follicular cell level through a number of different steps (Figure 56.1). The active transport of iodide into the follicular cells ismediated by the sodium iodide symporter (NIS) as the first crucial step in thyroid hormone synthesis (De la Viejaet al...
As several genes of the TH signaling pathway were also found in the sea urchin genome, we propose that the thyroid hormone signaling pathway is of ancestral origin in chordates, if not in deuterostomes, with specific elaborations in each lineage, including amphioxus. 展开 关键词: Branchiostoma...
Signaling pathways such as MAPK and P13K have been confirmed to be important in the mechanism of tumor genesis,development,prevention and treatment.Thyroid hormone(TH)and its receptor(TR)can affect the pathways resulting in inhibition of tumor growth and metastasis,thus they have gradually become the...
The steroid hormones released by granulosa cells are crucial for the normal development of follicles [26]. The interaction of T3 with the gonadotrophin hormone inhibiting excessive production of androgens by follicular membrane cells while simultaneously stimulating granulosa cells to secrete estrogen [27]...
The liver is controlled by several metabolic hormones, including thyroid hormone, and characteristically displays high lysosomal activity as well as metabolic stress-triggered autophagy, which is stringently regulated by the levels of hormones and metabo
(2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439: 484-489 As well as having a role in lipid absorption, bile acids can act as endocrine-signaling molecules. With previous studies suggesting that bile acids operate as metabolic integrators,...