The thyroid hormone signaling pathway has a wide range of functions in terms of individual development, maintenance of homeostasis, cell proliferation and differentiation, and glucose metabolism. Thyroid hormones are secreted by the thyroid gland, including thyroxine (T3) and triiodothyronine (T4). The...
(2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439: 484-489 As well as having a role in lipid absorption, bile acids can act as endocrine-signaling molecules. With previous studies suggesting that bile acids operate as metabolic integrators,...
Chang, Differential regulation of direct repeat 3 Vitamin D3 and direct repeat 4 thyroid hormone signaling pathway by the human TR4 orphan receptor, J. Biol. Chem. 274 (1999) 16198-16205.Lee et al., Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone...
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et al. Thyroid hormone receptor and ERRalpha coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Science signaling 11, https://doi.org/10.1126/scisignal.aam5855 (2018). Singh, B. K. et al. FoxO1 deacetylation regulates thyroid hormone-induced transcription of key ...
Thyroid hormones have vital roles in development, growth and energy metabolism. Within the past two decades, disturbances in thyroid hormone action have been implicated in ageing and the development of age-related diseases. This Review will consider resu
Angiotensin-(1–7) reduces cardiac effects of thyroid hormone by GSK3Β/NFATc3 signaling pathway Author links open overlay panelNathalia Senger 1 , Marcos Barrouin Melo 2 , Gabriela Placoná Diniz 1 , Maria José Campagnole-Santos 2 , Robson Augusto Souza Santos 2 , Maria Luiza M. Barreto...
catalyzing the conversion of tetraiodothyronine (T4) to T3 (active form of T4)[20], while KLF9, as a downstream target of thyroid hormone signaling, is involved in metabolic regulation and developmental processes[21], indicating that the thyroid hormone pathway is activated in cartilage of OA....
In this study, we will analyse how diabetes induces the reactivation of organs’ developmental programmes and growth, discuss how thyroid hormone (TH)
Thyroid hormone signaling in muscle development, repair and metabolism. J Endocrinol Diabetes Obes 2014;2:1046.Search in Google Scholar 79. Slater, CR. Postnatal maturation of nerve-muscle junctions in hindlimb muscles of the mouse. Dev Biol 1982;94:11–22. https://doi.org/10.1016/0012-1606(...