Key points: Plasma thyroid hormone (tri-iodo-l-thyronine; T3 ) concentrations rise near the end of gestation and is known to inhibit proliferation and stimulate maturation of cardiomyocytes before birth. Thyroid hormone receptors are required for the action of thyroid hormone in fetal cardiomyocytes....
(2004) Thyroid hormone receptor α is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci USA 101: 10332–10337 Article CAS PubMed PubMed Central Google Scholar Hernandez A et al. (2006) Type 3 deiodinase is critical for the maturation and function ...
is critical for normal testicular and reproductive function. The available evidence indicates the presence in the developing testis of a number of transporters,deiodinasesand receptors that could play a role in the timely delivery of TH action on testicular cells. These include the thyroid hormonerecep...
We have therefore carried out a number of tests of thyroid function in 10 children on human growth hormone treatment. Basal TSH levels and the TSH levels 20 minutes after an injection of TRH were normal in every case. In only one patient was the serum thyroxine level low and in this ...
A control experiment excluded possible interference on the hormone concentrations of administered donor blood and plasma. It is concluded that the thyroid hormones are not responsible for the posttraumatic hypermetabolism in burn injury. The present findings further indicate a depletion of metabolically ...
If there is any type of deficiency of thyroid hormones, a whole host of things in your body will go wrong, but you will be able to notice the effects of the hormone slump within four months of the thyroid hormone factory slowing down. ...
(TSH), a kind of master hormone that regulates the work of the thyroid gland. Along with TSH measurements , thyroid hormone levels are also analyzed. If TSH is high, it typically means that your thyroid function is too low (hypothyroid). If TSH is low, then it generally means the ...
Relationship between changes in thyroid hormone level and severity of the postoperative course in neonates undergoing open-heart surgery Background: Our aim was to determine whether the changes in thyroid function after open-heart surgery in neonates depend on the postoperative course. O Dagan,B Vid...
Disruption of thyroid hormone signalling can alter growth, development and energy metabolism. Thyroid hormones exert their effects through interactions with thyroid receptors that directly bind thyroid response elements and can alter transcriptional activity of target genes. The effects of short-term thyroid...
The Thyroid Hormone (TH) activating enzyme, type 2 Deiodinase (D2), is functionally required to elevate the TH concentration during cancer progression to advanced stages. However, the mechanisms regulating D2 expression in cancer still remain poorly understood. Here, we show that the cell stress ...