Thyroid physiology is altered during pregnancy as a result of an increase in thyroid-binding globulin, the stimulatory effect of hCG on TSH receptors, and increased peripheral thyroid hormone requirements. In a
Maternal demand for thyroid rises during pregnancy due to fetal use of thyroid hormones and an increase in thyroxine-binding globulin (TBG), among other reasons12. In particular, human chorionic gonadotrophin (hCG), which is structurally similar to TSH, significantly increases in early pregnancy, ...
Thyroid binding globulin (TBG) is the protein that transports thyroid hormone through the blood. When thyroid hormone is bound to TBG, it is inactive and unavailable to the tissues. When TBG levels are high, levels of unbound (free) thyroid hormone will be low, leading to hypothyroid symptoms...
Moreover compared with humans, thyroxin metabolism takes place more rapidly in rats because of the absence of thyroxin-binding globulin in the circulation. Rats are also more sensitive to thyroid peroxidase inhibition than humans.353 On balance, it appears that many drugs that are capable of ...
High doses of estrogen contained in birth control pills increase the activity of TBG (Thyroxine Binding Globulin), which binds thyroid hormone. More circulating TGB leads tolower levels of free thyroid hormoneavailable for use by the body. ...
2. Increased estrogen levels during pregnancy stimulate the liver to produce more thyroid-binding globulin (TBG), which in turn raises serum thyroid hormone levels. 3. The placenta synthesizes large amounts of human chorionic gonadotropin (HCG), which peaks around 3 months of pregnancy. HCG, wit...
Thyroxine binding globulin Tg: Thyroglobulin Th1: Type 1 helper T cell Th2: Type 2 helper T cell TPO: Thyroid peroxidase TR: Thyroid hormone receptor TREG: Regulatory CD4 + CD25 + T cells TSH: Thyrotrophin UIC: Urinary iodine concentration ...
Zadeh-Vakili A, Ramezani Tehrani F, Hashemi S, Amouzegar A, Azizi F. Relationship between sex hormone binding globulin, thyroid stimulating hormone, prolactin and serum androgens with metabolic syndrome parameters in Iranian women of reproductive age. Diabetes Metab. 2012;S:2.https://doi.org/10.4...
Thyroid binding globulin (TBG) is the protein that transports thyroid hormone through the blood. When thyroid hormone is bound to TBG, it is inactive and unavailable to the tissues. When TBG levels are high, levels of unbound (free) thyroid hormone will be low,leading to hypothyroid symptoms....
During pregnancy, the thyroid gland underwent significant physiological and biochemical changes. Elevated levels of human chorionic gonadotropin and estrogen indirectly contributed to an increase in thyroxine-binding globulin. These changes resulted in a 10%–40 % enlargement of the thyroid gland and a ...