19–21 In patients with thyroglobulin antibodies, serial monitoring of antibody levels in a single assay, can also sometimes be informative about the presence of residual disease and its progression or response to therapy.22–24 The ATA’s 2015 clinical practice guideline uses the postoperative ...
Monoclonal antibody MCO: Manufacturer cutoff NPV: Negative predictive value PAb: Polyclonal antibody PPV: Positive predictive value PTC: Papillary thyroid cancer PTH: Parathyroid hormone RAI: Radioiodine RF: Rheumatoid factor rhTSH: Recombinant human TSH RIA: Radioimmunoassay Tg: Thyroglobu...
When a high titer antibody is present, an appended comment reflecting the potential for positive or higher than reported Tg can help to ensure that the clinician is not falsely reassured by a low Tg level. 2.4.6.5 Reduction of thyroid hormone replacement doses in patients with thyroid cancer ...
positive Tg antibody (Tg-Ab > 115 IU/ml) and distant metastasis. Patients were classified into different stages (I, II, III, IVA and IVB) according to American Joint Committee on Cancer (AJCC) TNM staging. All patients were treated with total or near-total thyroidectomy, RAI remnant ablatio...
A serum sample was taken in each trimester for measurement of Tg and Tg antibody (TgAb), in the Regional Laboratory for Endocrinology at the Royal Victoria Hospital Belfast. Both Tg and TgAb were measured using the Electrochemiluminescence immunoassay (ECLIA) on Elecsys and Cobas e immunoassay ana...
This means that 12.5%–50% of reactive lymph nodes in postoperative patients in those studies had elevated Tg-FNA levels. An elevated threshold can reduce the false positive rate and avoid unnecessary surgery, which is important for thyroid carcinoma patients who have already undergone many rounds ...
Serum thyroglobulin (Tg) measurement is a major means of detecting thyroid cancer recurrence. Unlike anti-Tg autoantibody interferences, heterophile antibody (HAB) immunoassay interferences are not well recognized by laboratorians or clinicians as a Tg assay problem. When HAB interferences occur, they ...
TPOAb >34 IU/L and TGAb >115 IU/L were deemed to be elevated (i.e., positive). Statistical analysis The SPSS 19.0 software (IBM, Chicago, Illinois) was used to analyse the data. The measurements and normal distributions are expressed as means ± standard deviations, while values ...
Serum thyroglobulin (Tg) measurement is a major means of detecting thyroid cancer recurrence. Unlike anti-Tg autoantibody interferences, heterophile antibody (HAB) immunoassay interferences are not well recognized by laboratorians or clinicians as a Tg assay problem. When HAB interferences occur, they ...
In treated patients with T 3-suppressible thyroids, the serum thyroglobulin concentration was similar among those with positive (n = 54) and negative (n = 26) microsomal antibody, indicating that the presence of Hashimoto's thyroiditis does not profoundly affect the serum thyroglobulin level. ...