The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origi...
However the tests are subjective and lack high sensitivity. Enzyme-Linked Immunosorbent Assays (ELISAs) combine greater sensitivity, objective reading and ease of use. ELISAs have been developed and validated for detecting autoantibodies to thyroid antigens.Catalog Number KA...
Weigle WO, High GJ. The behaviour of autologous thyroglobulin in the circulation of rabbits immunized with either heterologous or altered homologous thyroglobulin. J Immunol. 1967;98:1105–14. CAS PubMed Google Scholar Igawa T, Haraya K, Hattori K. Sweeping antibody as a novel therapeutic antibo...
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Methods Establishment of animal model was performed with iodine and thyroglobulin(TG).The rats were randomly divided into 5 groups: normal control group(NC), low iodine group (LI,500 μg/L), high iodine group(HI,500 mg/L), TG+Freund adjuvant group(TG) and TG+Freund adjuvant+HI group(...
(Tg-Ab > 115 IU/ml) and distant metastasis. Patients were classified into different stages (I, II, III, IVA and IVB) according to American Joint Committee on Cancer (AJCC) TNM staging. All patients were treated with total or near-total thyroidectomy, RAI remnant ablation, and TSH-...
Outcome of differentiated thyroid cancer with detectable serum Tg and negative diagnostic (131)I whole body scan: comparison of patients treated with high ... Detectable serum Tg levels associated with negative diagnostic (131)I whole body scan are not infrequently found in patients with differentiate...
In our work, there are two main limitations. The first limitation is represented by the study population which was mainly composed of PTC and only in very small part by FTC. Such a high prevalence of PTC is common in iodine-deficient countries, such as southern Italy and Switzerland. Patient...
22.Bakkar, S, Al-Omar, K, Donatini, G, Aljarrah, Q, Papavramidis, TS, Materazzi, G, et al.. Postoperatively determined high-risk histopathologic features in papillary thyroid carcinoma initially eligible for thyroid lobectomy: a game changer.Endocrine2021;74:611–5.https://doi.org/10.1007...