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The idea that the thymus might be considered as an endocrine gland integrated in the complex hormonal network regulating the growth and the internal homeostasis of high organisms was first suggested by the observations that this organ seemed to be functionally active only before puberty, when the ma...
stands in juxtaposition to acute, stress-related involution, which is of diagnostic and therapeutic significance especially during childhood and adolescence. The latter represents an endogenous (e.g. illness-related) or exogenous (e.g. drug-related) very rapid acceleration of physiologic, age-related ...
In total, 72.7% patients had invasive thymoma while 27.3% had noninvasive tumor. In addition, there was a significant relationship between invasive thymoma rate and developing myasthenia gravis. The 3-year survival rate for all patients was equivalent to 83.3% however; 5-year survival was equal ...
They claimed that lycopene can protect mammalian cells against membrane and DNA damage and possibly play a protective role against tumor promotion (Matos et al., 2000). In a different study, lycopene treatment was caused less DNA damage than placebo treatment in Hep3B human hepatoma cells ...
This tumor arises from either ectopic thymus tissue or remnants of branchial pouches, which retain the potential to differentiate along the thymus line. Clinical presentation and imaging can be consistent with a malignant lesion such as thyroid cancer or thymic carcinoma. Immunohistochemical staining ...
Conversely, glucose supplementation enhanced the antitumor functions of IFN-γ+γδ T cells and reduced tumor growth upon adoptive transfer. These findings have important implications for the differentiation of effector γδ T cells and their manipulation in cancer immunotherapy. This is a preview of ...
Circulating mDCs can return to the thymus where they interact with TECs through direct cell–cell contact. MDCs can activate Notch signaling in TECs through the Jagged1/Notch3 axis. Long-term Notch signaling activation of TECs results in apoptosis and growth inhibition, further leading to the de...
Xian-jun Yang Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, 453003, Henan, China Na-na Li Department of Cellular and Molecular Biology, University of Texas Health Northeast, Tyler, TX, 75708, USA ...
The reproducibility of unique ultrasound features of IETs allows for safe long-term follow-up of these benign lesions in the majority of pediatric patients: not only monitoring the regression of IET but also screening towards the rare occurrence of a tumor arising from the IET....