Type 1 diabetes.Insulin plays a critical role in the growth of your thymus gland. You may have trouble with your thymus if you're born withtype 1 diabetes. This can cause a weakened immune system and related problems. Autoimmune disorders.A variety of autoimmune diseases are connected to thymu...
The thymus plays an important role in the defense against infection and cancer as well as the prevention of autoimmune diseases. However, the thymus gland atrophies with age, which might have pathological functions, and in some circumstances, there is a congenital defect in the thymus. These ...
The thymus is a gland located in the heart of the chest. Its main function is to produce and secrete T-lymphocytes, that are involved in fighting infection. The thymus also releases hormones, such as thyroxine and cortisol, which regulat...
The thymus gland plays an important role in the pathogenesis of myasthenia gravis and thymectomy is indicated in certain subgroups. Lambert-Eaton myasthenic ... M Montanari,C Romerio - 《Lille Medical Journal De La Faculte De Medecine Et De Pharmacie De Luniversite De Lille》 被引量: 7发表: ...
Function of the Microenvironment in Maturation It is generally accepted that the epithelial microenvironment of thethymic cortexplays a major role in positive selection. This microenvironment expresses MHC class I and class II products, and ultrastructurally is characterized by close interactions with lymph...
(anatomy, immunology) A ductless gland, consisting mainly of lymphatic tissue, located behind the top of the breastbone. It is most active during puberty, after which it shrinks in size. It plays an important role in the development of the immune system and produces lymphocytes.[..] ...
Apoptosis plays an essential role in maintaining cellular homeostasis during development, differentiation, and pathophysiological processes. In the immune ... E. W. and Sun,YF Shi - 《Pharmacol Ther》 被引量: 271发表: 2001年 A central role for thymic emigrants in peripheral T cell homeostasis Af...
Thethymusis a primarylymphoid organthat plays an important role in the differentiation of T-cells. It is formed by the fusion of the right and left thymic rudiments, originating from theectodermof the third branchial cleft and theendodermof the third branchial pouch, and moves caudally and medi...
Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. Notch1 signalling is essential for the commitment of multipotent lymphocyte precursors towards the alphabeta T-cell lineage and plays an important role in ......
The thymus is a lobulated unique lymphoid immune organ that plays a critical role in the selection, development, proliferation, and differentiation of T cells. The thymus of developing chickens undergoes continued morphological alterations; however, the biomolecular and transcriptional dynamics of the post...