17.Nucleotide excision repair is particularly important in correcting thymine dimers, which are primarily caused by ultraviolet light. 18.Adenine and thymine are connected by two hydrogen bonds, and cytosine and guanine are connected by three hydrogen bonds. ...
Interestingly, Tdg−/− MEFs are not sensitized to IR or hydrogen peroxide, suggesting that TDG activity is not important for removing the oxidized DNA base damage caused by these agents (Cortazar et al., 2011). Instead, the embryonic lethality of Tdg−/− mice appears to be due to ...
∇2ρ(r) > 0 is characterized by a closed-shell interaction (including H-bonding and π-stacking), in which the ρ(r) value is typically small or, more specifically, ~0.01 a.u. or less for H-bonding interaction and ~0.001 a.u. for van der Waals contact [101]. Figure 6. ...