Publisher Summary This chapter describes the purification procedure of thymidine phosphorylase enzyme from Salmonella typhimurium. In Escherichia coli and Salmonella typhimurium, thymidine phosphorylase plays an important role in the metabolism of thymine auxotrophs and is necessary for the conversion of ...
Thymidine phosphorylase (TP) is the enzyme responsible for conversion of FU to its active metabolite fluorodeoxyuridine monophosphate. TP was also proved to be an angiogenesis-promoting factor with a similar structure to that of platelet-derived endothelial cell growth factor (PD-ECGF)1 and played ...
Background: PD-ECGF/Thymidine Phosphorylase PD-ECGF, also known as TPase and gliostatin, is produced by placenta, platelets, liver, lung, spleen, lymph nodes, and peripheral lymphocytes. It is overexpressed by many tumors in response to chemical or physical stress. PD-ECGF promotes endothelial...
Thymidine phosphorylase (TP; encoded by TYMP) is a cytosolic enzyme that catalyzes the conversion of thymidine and deoxyuridine to thymine and uracil, respectively. From:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,2017
micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain human TP (Thymidine Phosphorylase), biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate ...
Clin Breast Cancer 3: 55 – 64 Yamamoto Y, Toi M, Tominaga T (1996) Prediction of the effect of 50- deoxy-5-fluorouridine by the status of angiogenic enzyme thymidine phosphorylase expression in recurrent breast cancer patients. Oncol Rep 3: 863 – 865 Yang Q, Barbaresch M, Mori I,...
Recombinant Thymidine Phosphorylase (TP) TYMP; PDECGF; ECGF1; MNGIE; TP; HPD-ECGF; TdRPase; Platelet-Derived Endothelial Cell Growth Factor; Gliostatin Enzyme & Kinase Tumor immunity Product No.RPA948Mu01 Organism SpeciesMus musculus (Mouse)Same name, Different species....
1. Thymidine overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues. 别名 Deoxyribothymidine , NSC 21548 , Thymidin , DThyd , 5-Methyldeoxyuridine,胸苷 纯度 98% 分子量 242.23
背景与目的血小板衍化内皮细胞生长因子/胸苷磷酸化酶(platelet-derivedendothelialcellgrowthfactor/thymidinephosphorylase,PD-ECGF/TP)是去氧氟尿苷和5-氟尿嘧啶在体内转化成活性抗癌物质的重要酶,它受到白细胞介素-1、γ干扰素等细胞因子的调节。 2. Purpose To detect the plasma level of platelet derived endothelial...
Afterwards, inhibitory potential of synthesized ciprofloxacin 2, 3a-3c, 4a-4d, 5a-5b, 6 and 7 against thymidine phosphorylase enzyme was assessed. Out of these twelve analogs of ciprofloxacin nine analogues 3a-3c, 4a-4c, 5a-5b and 6 showed good inhibitory activity against thymidine phosphorylase...