Thymidine phosphorylase in cancer; enemy or friend? Cancer Microenv. 2016, 9, 33-43. [CrossRef]Y.Y. Elamin, S. Rafee, N. Osman, K.J. O0Byrne, K. Gately, Thymidine phos- phorylase in cancer; enemy or friend? Cancer Microenviron. 9 (2016) 33e43....
(B) Thymidine phosphorylase enzymatic activity of the various cancer cells. Colo320 had no detectable TP activity. Values are means of at least three independent experiments ±s.e.m. (C) Western blot of cancer cell lines expression of the kinases (phosphorylated) FAK, Akt and p70/S6k in ...
OPEN SUBJECT AREAS: TRANSLATIONAL RESEARCH PROGNOSTIC MARKERS BOWEL CANCER Received 21 February 2014 Accepted 23 June 2014 Published 16 July 2014 Thymidine phosphorylase gene variant, platelet counts and survival in gastrointestinal cancer patients treated by fluoropyrimidines Liu Huang1, Fengju Chen1*, ...
Hirotoshi Utsunomiya,Hirokazu Ueshima,Mari Kawashiro,Qifeng Yang,Misa Nakamura,Yasushi Nakamura,Takeo Sakurai,Ichiro Mori,Kennichi Kakudo. Thymidine phosphorylase is regulated by tamoxifen in T47D breast cancer cell line[J]. Breast Cancer . 2002 (2)...
Thymidine phosphorylase is indeed upregulated by several anticancer drugs in human breast cancer cells, including both tumour and stromal cells; however, there are variations in the level. Thus, it is important to consider an individual strategy for sensitisation of breast tumour tissues to 5-FU ...
phosphorylaseshad been based on the faulty assumption that theenzymeis characterized by a dissociative transition state. A chemical screening program has provided a nanomolar inhibitor (called TPI) now being evaluated as an anti-cancer agent[52]. Computationalchemistryefforts have also predicted the ...
Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment 2005, Lancet Oncology Citation Excerpt : Transcriptional control of TP during pathological conditions is still unclear. The human epidermoid carcinoma cell line A431 was reported to express 3·0 kb ...
Thymidine phosphorylase (TP) has diverse functions within cells, including increasing the sensitivity of cancer cells to cytotoxic drugs including 5-fluorouracil (5-FU) and methotrexate. However, the regulators of TP still remains largely unknown.In this study, we examined whether tamoxifen has specifi...
Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors Cancer Res., 60 (2000), pp. 6298-6302 View in ScopusGoogle Scholar Furukawa et al., 1992 T. Furukawa, A. Yoshimura, T. Sumizawa, M. Haraguchi, S. Akiyama, K. Fukui, M. Ishizawa, ...
et al. Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase. Cancer research 55, 1687–1690 (1995). CAS PubMed Google Scholar Matsushita, S. et al. The effect of a thymidine phosphorylase inhibitor on ...