Structures of thymidine kinase 1 of human and mycoplasmic origin. Proc. Natl Acad. Sci. USA 101, 17970–17975 (2004). Article CAS PubMed PubMed Central Google Scholar Li, Q. et al. Thymidine kinase 1 drives he
A Moloney murine leukemia virus-derived retroviral vector carrying the herpes simplex virus (HSV) thymidine kinase (TK) gene was constructed and subsequently transfected into 唯2 packaging cells, with resultant retrovims being transduced into XC rat hepatoma cells. Using HSV-TK gene-transduced XC (...
Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors. J Hepatol 2004; 40:291-7.Gerolami R,Uch R,Faivre J,et al.Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV...
This dual role of TK1 drives the proliferation of human hepatocellular carcinoma cells and liver tumor growth in mice. Our findings reveal a crucial mechanism by which growth factors promote tumor development through TK1-mediated DNA synthesis and glycolysis and highlight TK1 as a potential molecular...
Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors. Gerolami R,Uch R,Faivre J,et al. Journal of Hepatology . 2004Gerolami R,Uch R,Faivre J,Garcia S,Hardwigsen J,Cardoso J,Mathieu S,Bagnis C,Brechot C,Man...
Gene therapy for hepatocellular carcinoma: chemosensi- tivity conferred by adenovirus-mediated transfer of the HSV-1 thymi- dine kinase gene. Cancer Gene Therapy, 1995; 2: 191-7.Wills K N, Huang W M, Harris M P, et al. 1995. Gene therapy for hepatocellular carcinoma: chemosensitivity ...
Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for hepatocellular carcinoma. Cell Res 1999; 9: 225-235.Gao DC ,An W ,Dai J . Retrovirus2mediated herpes simplex virus t hymi2 dine kinase gene t herapy approach for hepatocellular carcinoma[J ] . Cell Res ,1999...
A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma. Cancer Gene Ther 2010; 17: 837-43.Sangro B et al. A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma. Cancer Gene Ther. 2010;17(12):837-43...
herpes simplex virus thymidine kinase, mouse model, hepatocellular carcinoma, transcriptome analysisInflammation and fibrosis in human liver are often precursors to hepatocellular carcinoma (HCC), yet none of them is easily modeled in animals. We previously generated transgenic mice with hepatocyte-specific...
In this paper we attempted to create chimeric livers by inducing persistent hepatocellular damage in immunodeficient Rag2-/- 纬c-/- mice using an adenovirus encoding herpes virus thymidine kinase (AdTk) and two consecutive doses of ganciclovir (GCV). We found that this treatment resulted in ...