This example shows how to work with consumer credit panel data to create through-the-cycle (TTC) and point-in-time (PIT) models and compare their respective probabilities of default (PD). The PD of an obligor is a fundamental risk parameter in credit risk analysis. The PD of an obligor ...
point-in-time and through-the-cycle probability of defaultmodel calibrationasymptotic single risk factor modelmaximum likelihoodrating migration.The paper argues for the need for and importance of the dual calibration of a probability of default (PD) model (ie, calibration to both point-in-time (...
Ferroptosis, a non-apoptotic form of cell death induced by accumulation of free iron ions and lipid peroxidation, its importance for cancer treatment is gradually being recognized. Research on the anti-cancer mechanism of juglone is accumulating. However
Since then, studies have demonstrated that CIEs are diverse and important - in many cases, encoding key aspects of organismal function. Cytoplasmically inherited elements vary in their level of integration with the host - in the case of organelles, the proteome is jointly encoded in nuclear and ...
Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation ArticleOpen access23 September 2021 Identification of a long non-coding RNA regulator of liver carcinoma cell survival ...
Role of Autophagy in Tumor Progression and Regression Chapter © 2016 Introduction Immune checkpoint blockades (ICBs) targeting PD-1/PD-L1 or CTLA4 have revolutionized the current cancer therapy paradigm based on their high durability1,2,3. However, only a small subset of cancer patients shows ...
Poriferans (sponges) are highly adaptable organisms that can thrive in diverse marine and freshwater environments due, in part, to their close associations with internal microbial communities. This sponge microbiome can be acquired from the surrounding e
Your manual_concat function does not give the same output as pd.concat, in particualt the columns are ordered differently. To ensure the result, your compare_dataframes should be: def compare_dataframes(df1, df2): return df1.equals(df2) The ordering difference may be the reason for the ...
Hypertrophic scar (HS) considerably affects the appearance and causes tissue dysfunction in patients. The low bioavailability of 5-fluorouracil poses a challenge for HS treatment. Here we show a separating microneedle (MN) consisting of photo-crosslinked
These metabolic differences, referred to as metabolic vulnerability, between cancerous and normal cells are broadly found in TNBC, which exhibit the inevitable dependence on the mitochondrial TCA cycle, with slight differences observed in TNBC subtypes. It was also strongly suggested that tumors with ...