The term “refractory” has been used to refer to patients who failed splenectomy,48 but given the declining rate of splenectomy in ITP,49 it will not be used here. ITP in adults The treatment landscape has changed considerably; rituximab, eltrombopag, avatrombopag, and romiplostim are well ...
Many of these syndromes have extrahematopoietic manifestations, and even within the hematopoietic compartment, there is increasing evidence that genes previously thought to be platelet-restricted in their effects may actually have a broader impact on overall blood cell formation. Although many of the ...
The majority of children will not have undergone splenectomy, and those who have are likely to respond at least transiently, therefore the term refractory in this population may not be useful in distinguishing individuals with the highest risk of bleeding.9,10 The vast majority of children will ...
For patients receiving heparin in whom the risk of HIT is considered low (<0.1%), the American Society of Hematology (ASH) guideline panel suggests against platelet count monitoring to screen for HIT (conditional recommendation, very low certainty in the evidence about effects ⊕◯◯◯). ...
As the laboratory with which I am associated—the McMaster Platelet Immunology Laboratory—performs the serotonin-release assay (SRA) as its main platelet activation test, I will sometimes use the term “heparin-independent serotonin-release” (HISR) when referring to this special property of aHIT ...