149,150 These gain of function mutations prompt GP‐Ibα to exhibit an increased affinity for VWF, and spontaneous binding of VWF to platelets occurs. As a result, circulating plasma levels of VWF multimers are low, and thrombocytopenia is noted, presumably caused by the increased clearance of ...
There is no specific diagnostic test for TTP and in practice for management purposes the diagnosis is based on laboratory confirmation of thrombocytopenia and microangiopathic hemolytic anemia without an apparent alternative cause and with or without the characteristic clinical features described above. Man...
Finally, the administration of new antiaggregants that modify platelet aggregation by a different mechanism than aspirin can be an alternative for patients who have a recurrent stroke while receiving aspirin. Aspirin Toxicity Gastrointestinal irritation and bleeding, well-known side effects of aspirin, ...
In addition, because of the risk of significant thrombosis, transition to an alternative anticoagulant is recommended. Warfarin should not be used as a substitute for heparin during an acute HIT episode because it can result in an abrupt decrease in protein C levels, placing the patient at ...
attenuates antiplatelet antibody production and may be useful as a second-line therapy or as an alternative to splenectomy. However, rituximab may allow reactivation of latent viruses, potentially leading to fatal hepatitis B or progressive multifocal leukoencephalopathy (Jakob-Creutzfeldt virus). Thrombopoi...
negatively charged surface of PS-containing platelet-derived membranes is at least partly responsible for this rate enhancement, although there is not universal agreement on mechanism by which this occurs. Our efforts have led to an alternative view, namely that PS molecules bind to discrete ...
New oral anticoagulants are preferred over VKA, and may be considered as alternative treatment options [27,29–31]. Antiphospholipid Antibodies Antiphospholipid syndrome (APS) is an autoimmune prothrombotic state associated with arterial and venous thrombosis, recurrent fetal loss, and thrombocytopenia. ...