L10 Little, M.P. Threshold and other departures from linear-quadratic curvature in the non-cancer mortality dose-response curve in the Japanese atomic bomb sur- vivors. Radiat. Environ. Biophys. 43(2): 67-75 (2004).Little MP. Threshold and other departures from linear-quadratic curvature in...
The emerging battlefield: should the use of a nonmonotonic, non-threshold dose-response curve for alleged endocrine-disrupting chemicals survive a Daubert/Frye challenge? For radiation protection purposes, the threshold dose for the occurrence of biological damage is referred to as the effective dose...
For non-threshold chemicals, the dose-response curve is – or is presumed to be – smoother and more uniform (constant slope), and intersects the dose-response plot at the zero point. 对于没有临界点的化学品,剂量一反应曲线比较平坦和均匀, 或据推定比较平坦和均匀(坡度稳定),并在零点上与剂量一...
But the dose-response curve has not previously been fully determined, with some research suggesting a U-shaped curve between the two."The dose–response curve indicated that the association was generally linear across the range of vitamin D from 20 to 60 nmol/L," they state in their paper, ...
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For non-threshold chemicals, the dose-response curve is – or is presumed to be – smoother and more uniform (constant slope), and intersects the dose-response plot at the zero point. 对于没有临界点的化学品,剂量一反应曲线比较平坦和均匀, 或据推定比较平坦和均匀(坡度稳定),并在零点上与剂量...
H Dose response curve with CI of FLOT combination treatment grouped according to the patients' pathological response with calculated threshold curve and calculated AUCthreshold(FLOT). Blue lines represent pathological non-responders, black lines are pathological responders. I FLOT combination test results ...
ionising radiation, including the tumour biology [35]. The interpretation of the correlation between absorbed dose and biological effect depends on where the absorbed dose value of the lesion is located on the “absorbed dose–response curve”, i.e., in which zone (zone 1, 2 or 3, see ...
Sensitivity-corrected dose-response curves were then constructed using a general-order kinetic (GOK) function68, and the sensitivity-corrected natural OSL signal from each grain was projected onto the corresponding fitted DRC to estimate the De value. All data analyses, including curve fitting, De ...
effects than “a mild dose of flu” (Comment, 2 December 1995) has serious consequences for radiation protection. In any one individual, DNA repair may well function to produce a linear or threshold response. But if, as seems likely, the gradient of the response curve (or the threshold ...